Sequence Detail

ID/Version

Q62388 E9QNY7 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Serine-protein kinase ATM; EC=2.7.11.1 {ECO:0000269|PubMed:11571274};AltName: Full=Ataxia telangiectasia mutated homolog; Short=A-T mutated homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 3066 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atm	ataxia telangiectasia mutated	148	121	3	50

Sequence references in MGI

J:33931 Pecker I, et al., Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. Genomics. 1996 Jul 1;35(1):39-45
J:34193 Barlow C, et al., Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell. 1996 Jul 12;86(1):159-71
J:49187 Soares HD, et al., Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia. Neuroscience. 1998 Oct;86(4):1045-54
J:149451 Hewitt SL, et al., RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol. 2009 Jun;10(6):655-64
J:265834 Hung PJ, et al., MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018 Jul 19;71(2):332-342.e8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306588 Zhao B, et al., Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability. Cell Stem Cell. 2015 Jun 4;16(6):684-98
J:314385 Adams CJ, et al., ATM and Chk2 kinase target the p53 cofactor Strap. EMBO Rep. 2008 Dec;9(12):1222-9
J:341403 Burma S, et al., ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem. 2001 Nov 9;276(45):42462-7