Sequence Detail

ID/Version

Q62406 Q6Y3Z6 B1AUW4 Q6Y3Z5 (UniProt | EBI)

Last sequence update: 2001-08-14
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Interleukin-1 receptor-associated kinase 1; Short=IRAK; Short=IRAK-1; EC=2.7.11.1;AltName: Full=Pelle-like protein kinase; Short=mPLK;

Provider

SWISS-PROT

Sequence

Polypeptide 710 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irak1	interleukin-1 receptor-associated kinase 1	78	100	3	10

Sequence references in MGI

J:34345 Trofimova M, et al., Developmental and tissue-specific expression of mouse pelle-like protein kinase. J Biol Chem. 1996 Jul 26;271(30):17609-12
J:60688 Reichwald K, et al., Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions. Mamm Genome. 2000 Mar;11(3):182-90
J:67984 Vig E, et al., SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. J Biol Chem. 2001 Mar 16;276(11):7859-66
J:79541 Yu KY, et al., Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling. J Immunol. 2002 Oct 15;169(8):4075-8
J:97993 Uematsu S, et al., Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med. 2005 Mar 21;201(6):915-23
J:169840 Saitoh T, et al., Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells. Immunity. 2011 Mar 25;34(3):352-63
J:179016 Iwasaki H, et al., The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat Immunol. 2011 Dec;12(12):1167-75