Sequence Detail

ID/Version

Q63959 D3YZV2 E9Q5E5 Q62088 (UniProt | EBI)

Last sequence update: 2020-10-07
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Voltage-gated potassium channel KCNC3 {ECO:0000305};AltName: Full=KSHIIID {ECO:0000250|UniProtKB:Q01956};AltName: Full=Potassium voltage-gated channel subfamily C member 3;AltName: Full=Voltage-gated potassium channel subunit Kv3.3 {ECO:0000

Provider

SWISS-PROT

Sequence

Polypeptide 769 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	32	103	4	8

Sequence references in MGI

J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
J:17480 Goldman-Wohl DS, et al., Kv3.3b: a novel Shaw type potassium channel expressed in terminally differentiated cerebellar Purkinje cells and deep cerebellar nuclei. J Neurosci. 1994 Feb;14(2):511-22
J:71179 Espinosa F, et al., Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3. J Neurosci. 2001 Sep 1;21(17):6657-65
J:100344 McMahon A, et al., Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3. Eur J Neurosci. 2004 Jun;19(12):3317-27
J:123641 Joho RH, et al., Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice. Genes Brain Behav. 2006 Aug;5(6):472-82
J:134973 Hurlock EC, et al., Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants. J Neurosci. 2008 Apr 30;28(18):4640-8
J:139895 Desai R, et al., Protein kinase C modulates inactivation of Kv3.3 channels. J Biol Chem. 2008 Aug 8;283(32):22283-94
J:217960 Irie T, et al., Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells. J Physiol. 2014 Jan 1;592(Pt 1):229-47
J:234410 Zhang Y, et al., Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell. 2016 Apr 7;165(2):434-48
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87