Sequence Detail

ID/Version

Q68FD7 Q80T72 Q8BQM0 (UniProt | EBI)

Last sequence update: 2004-10-11
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Folliculin-interacting protein 1 {ECO:0000303|PubMed:25775561};

Provider

SWISS-PROT

Sequence

Polypeptide 1165 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fnip1	folliculin interacting protein 1	48	96	3	12

Sequence references in MGI

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:189078 Baba M, et al., The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development. Blood. 2012 Aug 9;120(6):1254-61
J:201276 Betschinger J, et al., Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell. 2013 Apr 11;153(2):335-47
J:220672 Hasumi H, et al., Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1624-31
J:234285 Siggs OM, et al., Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3706-15
J:262829 Centini R, et al., Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation. PLoS One. 2018;13(6):e0197973
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296897 Manford AG, et al., A Cellular Mechanism to Detect and Alleviate Reductive Stress. Cell. 2020 Oct 1;183(1):46-61.e21
J:338230 Manford AG, et al., Structural basis and regulation of the reductive stress response. Cell. 2021 Oct 14;184(21):5375-5390.e16
J:343014 Malik N, et al., Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Science. 2023 Apr 21;380(6642):eabj5559
J:346110 Yin Y, et al., FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. J Exp Med. 2022 May 2;219(5):e20212491