ID/Version |
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Sequence description from provider |
RecName: Full=ARF GTPase-activating protein GIT1; Short=ARF GAP GIT1;AltName: Full=G protein-coupled receptor kinase-interactor 1;AltName: Full=GRK-interacting protein 1; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
770
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:120748
Segura I, et al., Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nat Neurosci. 2007 Mar;10(3):301-10
J:141061 Angrand PO, et al., Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics. 2006 Dec;5(12):2211-27 J:150460 Schmalzigaug R, et al., Impaired fear response in mice lacking GIT1. Neurosci Lett. 2009 Jul 17;458(2):79-83 J:158848 Menon P, et al., Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 4;1317:218-26 J:158935 Pang J, et al., G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation. 2009 Mar 24;119(11):1524-32 J:171608 Won H, et al., GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Nat Med. 2011 May;17(5):566-72 J:205503 Fiuza M, et al., GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20807-12 J:213433 Yin G, et al., Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice. PLoS One. 2014;9(2):e89127 J:217270 Hagemann N, et al., The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. Oncogene. 2013 Sep 26;32(39):4602-13 J:259711 Martyn AC, et al., GIT1 regulates synaptic structural plasticity underlying learning. PLoS One. 2018;13(3):e0194350 J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 J:297321 Hong ST, et al., A Critical Role of GIT1 in Vertebrate and Invertebrate Brain Development. Exp Neurobiol. 2015 Mar;24(1):8-16 J:297330 Zhao SJ, et al., Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way. J Bone Miner Res. 2020 Oct;35(10):2015-2031 J:319812 Badea A, et al., Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging. Magn Reson Imaging. 2021 Feb;76:26-38 J:319814 Li L, et al., GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-kappaB/Notch signalling to promote angiogenesis. Cell Prolif. 2019 Nov;52(6):e12689 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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