Sequence Detail

ID/Version

Q75N73 Q8VDL0 A0A0R4J1V1 Q80U85 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Metal cation symporter ZIP14 {ECO:0000305|PubMed:18270315};AltName: Full=Factor for adipocyte differentiation 123 {ECO:0000312|EMBL:BAD16742.1}; Short=FAD-123 {ECO:0000312|EMBL:BAD16742.1};AltName: Full=Solute carrier family 39 membe

Provider

SWISS-PROT

Sequence

Polypeptide 489 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc39a14	solute carrier family 39 (zinc transporter), member 14	58	100	3	83

Sequence references in MGI

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:99063 Liuzzi JP, et al., Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A. 2005 May 10;102(19):6843-8
J:113753 Liuzzi JP, et al., Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13612-7
J:149697 Lichten LA, et al., Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G860-7
J:171670 Hojyo S, et al., The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth. PLoS One. 2011;6(3):e18059
J:177624 Pinilla-Tenas JJ, et al., Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. Am J Physiol Cell Physiol. 2011 Oct;301(4):C862-71
J:192300 Beker Aydemir T, et al., Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). PLoS One. 2012;7(10):e48679
J:223870 Guthrie GJ, et al., Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G171-8
J:237352 Aydemir TB, et al., Hepatic ZIP14-mediated Zinc Transport Contributes to Endosomal Insulin Receptor Trafficking and Glucose Metabolism. J Biol Chem. 2016 Nov 11;291(46):23939-23951
J:243199 Aydemir TB, et al., Metal Transporter Zip14 (Slc39a14) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity. J Neurosci. 2017 Jun 21;37(25):5996-6006
J:244724 Kim MH, et al., Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5805-E5814
J:261326 Hendrickx G, et al., Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis. PLoS Genet. 2018 Apr;14(4):e1007321
J:272189 Sterling J, et al., Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels. Exp Eye Res. 2017 Feb;155:15-23
J:274233 Sasaki S, et al., Disruption of the mouse Slc39a14 gene encoding zinc transporter ZIP14 is associated with decreased bone mass, likely caused by enhanced bone resorption. FEBS Open Bio. 2018 Apr;8(4):655-663
J:281105 Scheiber IF, et al., The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis. J Biol Chem. 2019 Jun 7;294(23):9147-9160
J:282601 Girijashanker K, et al., Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter. Mol Pharmacol. 2008 May;73(5):1413-23
J:284990 Zhao N, et al., ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin. J Biol Chem. 2010 Oct 15;285(42):32141-50
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:299580 Jenkitkasemwong S, et al., SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis. Cell Metab. 2015 Jul 7;22(1):138-50