Sequence Detail

ID/Version

Q8BJ56 Q3UD97 Q05BJ0 Q643S0 Q9DCF6 Q6P234 O89080 Q9D1Q9 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Patatin-like phospholipase domain-containing protein 2 {ECO:0000305}; EC=3.1.1.3 {ECO:0000269|PubMed:15337759, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16675698, ECO:0000269|PubMed:16679289, ECO:00

Provider

SWISS-PROT

Sequence

Polypeptide 486 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pnpla2	patatin-like phospholipase domain containing 2	43	98	3	12

Sequence references in MGI

J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108546 Haemmerle G, et al., Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science. 2006 May 5;312(5774):734-7
J:117712 Schweiger M, et al., Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem. 2006 Dec 29;281(52):40236-41
J:118169 Miyoshi H, et al., Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes. J Biol Chem. 2007 Jan 12;282(2):996-1002
J:129650 Lass A, et al., Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab. 2006 May;3(5):309-19
J:189193 Pagnon J, et al., Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase. Endocrinology. 2012 Sep;153(9):4278-89
J:192630 Eichmann TO, et al., Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem. 2012 Nov 30;287(49):41446-57
J:207817 Granneman JG, et al., Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase. J Biol Chem. 2011 Feb 18;286(7):5126-35
J:289460 Zimmermann R, et al., Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 2004 Nov 19;306(5700):1383-6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:322693 Villena JA, et al., Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem. 2004 Nov 5;279(45):47066-75
J:330448 Patel R, et al., ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature. 2022 Jun;606(7916):968-975