ID/Version |
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Sequence description from provider |
RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=mMad3;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
425
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:57220
Kano K, et al., Cloning and studies of the mouse cDNA encoding Smad3. J Vet Med Sci. 1999 Mar;61(3):213-9
J:59673 Ashcroft GS, et al., Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response [see comments]. Nat Cell Biol. 1999 Sep;1(5):260-6 J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92 J:65990 Miura S, et al., Hgs (Hrs), a FYVE domain protein, is involved in smad signaling through cooperation with SARA. Mol Cell Biol. 2000 Dec;20(24):9346-55 J:79484 Jiao K, et al., Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1. Mol Cell Biol. 2002 Nov;22(21):7633-44 J:92664 Lin HK, et al., Cytoplasmic PML function in TGF-beta signalling. Nature. 2004 Sep 9;431(7005):205-11 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:106894 Collart C, et al., Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein. Genes Cells. 2005 Sep;10(9):897-906 J:111518 Borton AJ, et al., The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. J Bone Miner Res. 2001 Oct;16(10):1754-64 J:122005 Mavrakis KJ, et al., Arkadia Enhances Nodal/TGF-beta Signaling by Coupling Phospho-Smad2/3 Activity and Turnover. PLoS Biol. 2007 Mar 6;5(3):e67 J:122807 Warner DR, et al., PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue. Biochim Biophys Acta. 2007 Jun;1773(6):814-20 J:140377 Esguerra CV, et al., Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. Development. 2007 Dec;134(24):4381-93 J:148556 Blount AL, et al., FoxL2 and Smad3 coordinately regulate follistatin gene transcription. J Biol Chem. 2009 Mar 20;284(12):7631-45 J:169049 Varelas X, et al., The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. Dev Cell. 2010 Dec 14;19(6):831-44 J:175198 Ashcroft GS, et al., Role of Smad3 in the hormonal modulation of in vivo wound healing responses. Wound Repair Regen. 2003 Nov-Dec;11(6):468-73 J:175326 Kawakatsu M, et al., Loss of Smad3 gives rise to poor soft callus formation and accelerates early fracture healing. Exp Mol Pathol. 2011 Feb;90(1):107-15 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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