Sequence Detail

ID/Version

Q8C5L6 O09040 (UniProt | EBI)

Last sequence update: 2004-03-15
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Inositol polyphosphate 5-phosphatase K {ECO:0000305}; EC=3.1.3.56 {ECO:0000269|PubMed:22247557, ECO:0000269|PubMed:22751929};AltName: Full=Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; EC=3.1.3.86 {ECO:0000250|UniPr

Provider

SWISS-PROT

Sequence

Polypeptide 468 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Inpp5k	inositol polyphosphate 5-phosphatase K	108	97	4	15

Sequence references in MGI

J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:185086 Ijuin T, et al., Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP). J Biol Chem. 2012 Mar 2;287(10):6991-9
J:188803 Ijuin T, et al., Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1. Mol Cell Biol. 2012 Sep;32(17):3570-84
J:262332 Wiessner M, et al., Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment. Am J Hum Genet. 2017 Mar 2;100(3):523-536
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89