ID/Version |
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Sequence description from provider |
RecName: Full=Histone acetyltransferase KAT5 {ECO:0000305}; EC=2.3.1.48 {ECO:0000305|PubMed:32542325};AltName: Full=60 kDa Tat-interactive protein {ECO:0000303|PubMed:12036595}; Short=Tip60 {ECO:0000303|PubMed:12036595};AltName: Full=Histo | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
513
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:77074
McAllister D, et al., Characterization and expression of the mouse tat interactive protein 60 kD (TIP60) gene. Gene. 2002 May 1;289(1-2):169-76
J:83989 Legube G, et al., Identification of a larger form of the histone acetyl transferase Tip60. Gene. 2003 May 22;310:161-8 J:113460 Kim MS, et al., Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor. J Biol Chem. 2006 Jun 2;281(22):15082-9 J:125164 Gorrini C, et al., Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature. 2007 Aug 30;448(7157):1063-7 J:151916 Pan F, et al., Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science. 2009 Aug 28;325(5944):1142-6 J:183987 Lin SY, et al., GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science. 2012 Apr 27;336(6080):477-81 J:211791 Xiao Y, et al., Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. Cell Rep. 2014 Jun 12;7(5):1471-80 J:244731 Dong Y, et al., EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice. Mol Cell Biol. 2017 Oct 01;37(19) J:262920 Li TY, et al., Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018 May 15;9(1):1916 J:277685 Petkau N, et al., Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Elife. 2019 Jul 11;8:e43235 J:278470 Acharya D, et al., TIP55, a splice isoform of the KAT5 acetyltransferase, is essential for developmental gene regulation and organogenesis. Sci Rep. 2018 Oct 8;8(1):14908 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 J:293083 Li ML, et al., Phosphorylation of TIP60 Suppresses 53BP1 Localization at DNA Damage Sites. Mol Cell Biol. 2019 Jan 1;39(1) J:295963 Song ZM, et al., KAT5 acetylates cGAS to promote innate immune response to DNA virus. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21568-21575 J:304368 Numata A, et al., Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. Blood. 2020 Oct 8;136(15):1735-1747 J:319695 Jang SM, et al., KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation. Cell Death Dis. 2015 Aug 20;6:e1857 J:319944 Garcia-Gonzalez R, et al., VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage. Cancers (Basel). 2020 Oct 15;12(10):2986 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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