ID/Version |
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Sequence description from provider |
RecName: Full=DCC-interacting protein 13-beta {ECO:0000250|UniProtKB:Q8NEU8}; Short=Dip13-beta {ECO:0000303|Ref.1};AltName: Full=Adapter protein containing PH domain, PTB domain and leucine zipper motif 2 {ECO:0000305}; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
662
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:156351
Wang C, et al., Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. J Biol Chem. 2009 Nov 13;284(46):31608-15
J:226873 Mao L, et al., Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell Biosci. 2014;4(1):60 J:227340 Tan Y, et al., Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts. J Cell Physiol. 2016 May;231(5):1142-50 J:230004 Cheng KK, et al., The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes. 2014 Nov;63(11):3748-58 J:261013 Wang B, et al., Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system. EMBO Rep. 2018 Apr;19(4) J:268007 Yeo JC, et al., Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages. Traffic. 2016 Sep;17(9):1014-26 J:268015 Yeo JC, et al., Rab31 and APPL2 enhance FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages. Mol Biol Cell. 2015 Mar 1;26(5):952-65 J:268033 Gao C, et al., Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor. Mol Neurobiol. 2018 Jul;55(7):5537-5547 J:268172 Gao C, et al., Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. Mol Neurobiol. 2018 Dec;55(12):9334-9348 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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