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Sequence Detail
ID/Version
Q924Z4 Q9DCN6 Q3TXC5 (UniProt | EBI) Last sequence update: 2001-12-01
Last annotation update: 2024-07-24
Sequence
description
from provider
RecName: Full=Ceramide synthase 2 {ECO:0000303|PubMed:18165233}; Short=CerS2 {ECO:0000303|PubMed:18165233};AltName: Full=LAG1 longevity assurance homolog 2 {ECO:0000303|PubMed:15823095};AltName: Full=Sphingosine N-acyltransferase CERS2 {ECO:000030
Provider SWISS-PROT
Sequence
Polypeptide 380 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Cers2 ceramide synthase 2 21 105 4 49
Sequence references in MGI J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117553 Mizutani Y, et al., Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005 Aug 15;390(Pt 1):263-71
J:156841 Imgrund S, et al., Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem. 2009 Nov 27;284(48):33549-60
J:161189 Pewzner-Jung Y, et al., A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem. 2010 Apr 2;285(14):10902-10
J:197105 Yamashita-Sugahara Y, et al., Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor gamma target gene that regulates adipogenesis through ceramide synthesis. J Biol Chem. 2013 Feb 15;288(7):4522-37
J:230048 Novgorodov SA, et al., SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22;291(4):1957-73
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297974 Yang Y, et al., LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins. Biochem Biophys Res Commun. 2020 Jun 11;526(4):871-879

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/17/2024
MGI 6.24
The Jackson Laboratory