Sequence Detail

ID/Version

Q99MQ3 A2AM77 Q811I8 Q91XU5 Q7TMZ3 (UniProt | EBI)

Last sequence update: 2004-06-07
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase PINK1, mitochondrial; EC=2.7.11.1 {ECO:0000269|PubMed:24652937, ECO:0000269|PubMed:25474007, ECO:0000269|PubMed:32484300};AltName: Full=BRPK;AltName: Full=PTEN-induced putative kinase protein 1;Flags:

Provider

SWISS-PROT

Sequence

Polypeptide 580 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pink1	PTEN induced putative kinase 1	155	103	3	22

Sequence references in MGI

J:100301 Nakajima A, et al., BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett. 2003 Nov 25;201(2):195-201
J:140335 Gautier CA, et al., Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11364-9
J:146282 Xiong H, et al., Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest. 2009 Mar;119(3):650-60
J:209583 Morais VA, et al., PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science. 2014 Apr 11;344(6180):203-7
J:211292 Koyano F, et al., Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature. 2014 Jun 5;510(7503):162-6
J:225033 Morais VA, et al., Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med. 2009 May;1(2):99-111
J:255916 Huang E, et al., PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress. Nat Commun. 2017 Nov 9;8(1):1399
J:282679 Moutaoufik MT, et al., Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. iScience. 2019 Sep 27;19:1114-1132
J:302474 Han H, et al., PINK1 phosphorylates Drp1(S616) to regulate mitophagy-independent mitochondrial dynamics. EMBO Rep. 2020 Aug 5;21(8):e48686