Sequence Detail

ID/Version

Q9D1P2 Q8BJ76 Q3UIY0 Q8CI73 Q8BJ69 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Histone acetyltransferase KAT8 {ECO:0000305}; EC=2.3.1.48 {ECO:0000269|PubMed:31794431};AltName: Full=Lysine acetyltransferase 8 {ECO:0000303|PubMed:28506985};AltName: Full=MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 {ECO:0000303|PubMed

Provider

SWISS-PROT

Sequence

Polypeptide 458 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kat8	K(lysine) acetyltransferase 8	65	114	3	34

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120330 Dmitriev RI, et al., Characterization of hampin/MSL1 as a node in the nuclear interactome. Biochem Biophys Res Commun. 2007 Apr 20;355(4):1051-7
J:128936 Gupta A, et al., The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. Mol Cell Biol. 2008 Jan;28(1):397-409
J:139761 Thomas T, et al., Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture. Mol Cell Biol. 2008 Aug;28(16):5093-105
J:238087 Chatterjee A, et al., MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria. Cell. 2016 Oct 20;167(3):722-738.e23
J:238920 Valerio DG, et al., Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice. Blood. 2017 Jan 05;129(1):48-59
J:242000 Yin S, et al., Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels. Development. 2017 Jun 15;144(12):2165-2174
J:275220 Huai W, et al., KAT8 selectively inhibits antiviral immunity by acetylating IRF3. J Exp Med. 2019 Apr 1;216(4):772-785
J:282942 Karoutas A, et al., The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nat Cell Biol. 2019 Oct;21(10):1248-1260
J:297798 Li L, et al., Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability. J Clin Invest. 2020 Mar 2;130(3):1431-1445
J:313850 Chelmicki T, et al., MOF-associated complexes ensure stem cell identity and Xist repression. Elife. 2014 May 19;3:e02024
J:342004 Sincennes MC, et al., Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice. Nat Commun. 2021 May 31;12(1):3253
J:345005 Deng X, et al., Mammalian X upregulation is associated with enhanced transcription initiation, RNA half-life, and MOF-mediated H4K16 acetylation. Dev Cell. 2013 Apr 15;25(1):55-68
J:347144 Ravens S, et al., Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation. Elife. 2014 Jun 4;3
J:347290 Guhathakurta S, et al., COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Nat Metab. 2023 Nov;5(11):1931-1952