Sequence Detail

ID/Version

Q9JHI9 Q8BME5 Q8BUM5 Q9JIM9 Q9JKP4 Q3UHZ9 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Solute carrier family 40 member 1;AltName: Full=Ferroportin-1;AltName: Full=Iron-regulated transporter 1;AltName: Full=Metal transporter protein 1; Short=MTP1;

Provider

SWISS-PROT

Sequence

Polypeptide 570 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	40	105	3	15

Sequence references in MGI

J:60557 Donovan A, et al., Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter [see comments]. Nature. 2000 Feb 17;403(6771):776-81
J:60686 McKie AT, et al., A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000 Feb;5(2):299-309
J:63027 Abboud S, et al., A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000 Jun 30;275(26):19906-12
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:129846 Donovan A, et al., The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005 Mar;1(3):191-200
J:260761 Zhang DL, et al., Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk. Science. 2018 Mar 30;359(6383):1520-1523
J:269380 Zhang DL, et al., Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress. Blood. 2018 Nov 8;132(19):2078-2087
J:315675 Jiang L, et al., RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation. Blood. 2021 Aug 26;138(8):689-705
J:331986 Jin L, et al., Mice overexpressing hepcidin suggest ferroportin does not play a major role in Mn homeostasis. Metallomics. 2019 May 22;11(5):959-967