Sequence Detail

ID/Version

Q9JJZ2 D4P911 Q9CV57 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Tubulin alpha-8 chain; EC=3.6.5.- {ECO:0000250|UniProtKB:P68363};AltName: Full=Alpha-tubulin 8;Contains: RecName: Full=Dephenylalaninated tubulin alpha-8 chain;

Provider

SWISS-PROT

Sequence

Polypeptide 449 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tuba8	tubulin, alpha 8	16	112	2	14

Sequence references in MGI

J:61654 Stanchi F, et al., TUBA8: A new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. Biochem Biophys Res Commun. 2000 Apr 21;270(3):1111-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150280 Rogowski K, et al., Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell. 2009 Jun 12;137(6):1076-87
J:158294 Abdollahi MR, et al., Mutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia. Am J Hum Genet. 2009 Nov;85(5):737-44
J:169198 Braun A, et al., Tuba8 is expressed at low levels in the developing mouse and human brain. Am J Hum Genet. 2010 May 14;86(5):819-22; author reply 822-3
J:201638 Bosch Grau M, et al., Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. J Cell Biol. 2013 Aug 5;202(3):441-51
J:241131 Janke C, et al., Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science. 2005 Jun 17;308(5729):1758-62
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:300009 Gadadhar S, et al., Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Science. 2021 Jan 8;371(6525)