Sequence Detail

ID/Version

Q9WVH4 D3Z6Y6 Q05CZ4 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Forkhead box protein O3 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 672 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Foxo3	forkhead box O3	100	127	5	26

Sequence references in MGI

J:69574 Biggs III WH, et al., Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm Genome. 2001 Jun;12(6):416-25
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:130403 Zhao J, et al., FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 2007 Dec;6(6):472-83
J:130442 Mammucari C, et al., FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab. 2007 Dec;6(6):458-71
J:184684 Nakae J, et al., Novel repressor regulates insulin sensitivity through interaction with Foxo1. EMBO J. 2012 May 16;31(10):2275-95
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:210910 Wang F, et al., SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell. 2007 Aug;6(4):505-14
J:217746 Bowman CJ, et al., Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. Nat Cell Biol. 2014 Dec;16(12):1202-14
J:257318 Celestini V, et al., Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Cell Death Dis. 2018 Feb 14;9(2):231
J:257325 Peserico A, et al., A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell Mol Life Sci. 2013 Jun;70(11):2015-29
J:287060 van Gastel N, et al., Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature. 2020 Mar;579(7797):111-117
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89