ID/Version |
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Sequence description from provider |
RecName: Full=EGF-containing fibulin-like extracellular matrix protein 2 {ECO:0000305};AltName: Full=Fibulin-4 {ECO:0000303|PubMed:16478991}; Short=FIBL-4;AltName: Full=Mutant p53-binding protein 1;Flags: Precursor; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
443
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:65051
Gallagher WM, et al., MBP1: a novel mutant p53-specific protein partner with oncogenic properties. Oncogene. 1999 Jun 17;18(24):3608-16
J:106902 McLaughlin PJ, et al., Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. Mol Cell Biol. 2006 Mar;26(5):1700-9 J:121136 Kobayashi N, et al., A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization. J Biol Chem. 2007 Apr 20;282(16):11805-16 J:154659 Horiguchi M, et al., Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19029-34 J:170883 Huang J, et al., Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ Res. 2010 Feb 19;106(3):583-92 J:213282 Huang J, et al., Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice. Sci Transl Med. 2013 May 1;5(183):183ra58, 1-11 J:221200 Bultmann-Mellin I, et al., Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms. Dis Model Mech. 2015 Apr;8(4):403-15 J:223792 Igoucheva O, et al., Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities. J Biol Chem. 2015 Aug 28;290(35):21443-21459 J:226034 Papke CL, et al., Loss of fibulin-4 disrupts collagen synthesis and maturation: implications for pathology resulting from EFEMP2 mutations. Hum Mol Genet. 2015 Oct 15;24(20):5867-79 J:232351 Sasaki T, et al., Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking. Matrix Biol. 2016 Mar;50:53-66 J:258180 Halabi CM, et al., Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries. Sci Adv. 2017 May;3(5):e1602532 J:259726 Yamashiro Y, et al., Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice. Sci Signal. 2015 Oct 20;8(399):ra105 J:261872 Markova DZ, et al., Forelimb contractures and abnormal tendon collagen fibrillogenesis in fibulin-4 null mice. Cell Tissue Res. 2016 Jun;364(3):637-46 J:297323 Schiavinato A, et al., Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts. Sci Rep. 2017 Jul 17;7(1):5526 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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