ID/Version |
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Sequence description from provider |
RecName: Full=Oxysterols receptor LXR-alpha;AltName: Full=Liver X receptor alpha;AltName: Full=Nuclear receptor subfamily 1 group H member 3; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
445
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:60322
Alberti S, et al., Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Gene. 2000 Feb 8;243(1-2):93-103
J:150132 Zelcer N, et al., LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009 Jul 3;325(5936):100-4 J:206173 Rong X, et al., LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013 Nov 5;18(5):685-97 J:206917 Wada T, et al., Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol. 2008 Mar;73(3):891-9 J:220827 Rong X, et al., Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 2015;4 J:235724 Hsieh J, et al., TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature. 2016 Jul 14;535(7611):303-7 J:252691 Rong X, et al., ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest. 2017 Oct 02;127(10):3640-3651 J:320338 Washburn DG, et al., Synthesis and SAR of potent LXR agonists containing an indole pharmacophore. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1097-100 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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