Sequence Detail

ID/Version

Q9Z1S0 A2ARS1 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; EC=2.7.11.1;AltName: Full=MAD3/BUB1-related protein kinase; Short=BubR1;AltName: Full=Mitotic checkpoint kinase MAD3L;

Provider

SWISS-PROT

Sequence

Polypeptide 1052 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bub1b	BUB1B, mitotic checkpoint serine/threonine kinase	35	109	4	34

Sequence references in MGI

J:52194 Davenport JW, et al., The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner. Genomics. 1999 Jan 1;55(1):113-7
J:85203 Weaver BA, et al., Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol. 2003 Aug 18;162(4):551-63
J:88094 Dai W, et al., Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res. 2004 Jan 15;64(2):440-5
J:91128 Baker DJ, et al., BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet. 2004 Jul;36(7):744-9
J:128455 Perera D, et al., Bub1 maintains centromeric cohesion by activation of the spindle checkpoint. Dev Cell. 2007 Oct;13(4):566-79
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89