Sequence Detail

ID/Version

Q9Z2I0 Q7TMK8 Q80ZX6 Q8K5E5 Q5PQC5 Q8CGJ3 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Mitochondrial proton/calcium exchanger protein {ECO:0000305};AltName: Full=Electroneutral mitochondrial K(+)/H(+)exchanger {ECO:0000250|UniProtKB:O95202}; Short=KHE {ECO:0000250|UniProtKB:O95202};AltName: Full=Leucine zipper-EF-hand-

Provider

SWISS-PROT

Sequence

Polypeptide 738 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Letm1	leucine zipper-EF-hand containing transmembrane protein 1	33	98	3	13

Sequence references in MGI

J:57782 Endele S, et al., LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients. Genomics. 1999 Sep 1;60(2):218-25
J:222017 Jiang D, et al., Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2249-54
J:241038 Shao J, et al., Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2+/H+ antiporter. Sci Rep. 2016 Sep 27;6:34174
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89