Sequence Detail

ID/Version

Q9Z2V5 B1AUA6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Histone deacetylase 6; Short=HD6; EC=3.5.1.98 {ECO:0000269|PubMed:9891014};AltName: Full=Histone deacetylase mHDA2 {ECO:0000303|PubMed:9891014};AltName: Full=Protein deacetylase HDAC6 {ECO:0000305}; EC=3.5.1.- {ECO:00

Provider

SWISS-PROT

Sequence

Polypeptide 1149 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hdac6	histone deacetylase 6	175	110	2	21

Sequence references in MGI

J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
J:163064 Wickstrom SA, et al., CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J. 2010 Jan 6;29(1):131-44
J:166802 Yan W, et al., Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility. J Biol Chem. 2010 Oct 8;285(41):31418-26
J:209487 Southwood CM, et al., Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Neurochem Res. 2007 Feb;32(2):187-95
J:238090 Fukuda T, et al., Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor. EMBO Rep. 2016 Dec;17(12):1785-1798
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:338158 Zhang Y, et al., IPO7 Promotes Odontoblastic Differentiation and Inhibits Osteoblastic Differentiation Through Regulation of RUNX2 Expression and Translocation. Stem Cells. 2022 Nov 29;40(11):1020-1030