Using the Strain Search
Using the Strain Search
This help document answers the following questions:
See also:
You can search for strains by strain name and/or attribute. In the Strain Name field, start typing a strain name (such as C57BL/6J) or synonym (such as B6 for C57BL/6 strains) and an autocomplete list will appear. Select a strain from the list or add an asterisk (*) to your search name to perform a "begins" search. You can also use this field to search with an MGI strain ID, such as MGI:3028467 for C57BL/6J. You can also use this field to search with an MGI strain ID, such as MGI:3028467 for C57BL/6J.
You can limit your Strain Name field search to particular strain attributes or search by attributes without using the Strain Name field.
To select multiple attributes:
When you search with multiple attributes, by default, the search finds any attribute you selected. As an example, if you select deletion and spontaneous mutation, the search will return all deletion strains and all spontaneous mutation strains. You can toggle "any" to "all," to find strains that are associated with all your selected attributes.
To the right of the query portion of the page, this page also provides some prepared queries for popular Strain Collections, such as the 8 founder inbred strains used for the Collaborative Cross (CC) the Diversity Outcross (DO), and the Wellcome Sanger Institute's Mouse Genomes Project (MGP) strains.
The attributes are defined in the following table.
| Attribute | Definition | Example |
|---|---|---|
| chemically induced mutation | The exposure of mice to the chemical mutagens such as N-ethyl-N-nitrosourea (ENU), ethyl methanesulfonate (EMS), bleomycin, and chlorambucil, and resulting in germline transmissible mutations. | C57BL/6J-ApcMin/J |
| chromosome aberration | A chromosome rearrangement, or less commonly, an aneuploidy. | 129S-Del(6)1Mom/MomJ |
| closed colony | A closed colony contains limited genetic diversity, and is maintained neither by sib-mating (inbred), nor by selective mating to maximize heterozygosity (outbred). All matings occur within the colony members, but breeders need not be selected from specific parentage. No animals are introduced into the colony from outside the stock from generation to generation. | BR/ChapOrl[cc] |
| coisogenic | A strain that differs from a particular inbred strain at only one locus. A coisogenic strain arises when a mutation occurs in an inbred strain. | 129P2/OlaHsd-Hprtb-m3 |
| congenic | An inbred strain of mouse that contains a small genetic region (ideally a single gene) from another strain, but which is otherwise identical to the original inbred strain. | 129S/SvEv-Gpi1c |
| conplastic | Conplastic strains are developed by backcrossing the nuclear genome from one inbred strain into the cytoplasm of another, i.e. the mitochondrial parent is always the female parent during the backcrossing program. | C57BL/6J-mtA/J/NaJ |
| consomic | An inbred strain of mouse that contains a single entire chromosome from another strain. | C57BL/6JEi-Chr YAKR |
| deletion | A type of mutation caused by loss of one or more nucleotides from a DNA segment. Deletions can be very large, encompassing many genes and megabases of DNA, to the point of producing a visible cytological abnormality in a chromosome. | C.DDD-plt/NknoJ |
| duplication | An additional copy of a DNA segment present in the genome. | B6.129(Cg)-Dp(5Gtf2i-Gtf2ird1)1Lro/JcrwJ |
| endonuclease-mediated mutation | A type of engineered mutation in which a chromosomal gene is altered by the action of a RNA-guided DNA site-specific endonuclease, including the actions of the clustered regulatory interspaced short palindromic repeat (CRISPR/Cas9 )system, transcription activator-like effector nucleases (TALENS) or zinc finger nucleases (ZFN). These endonucleases induce a broad range of mutations by inducing DNA double-strand breaks that stimulate error-prone nonhomologous end joining (NEJ) or homology-directed repair (HDR) at specified genomic locations. | NOD/ShiLtDvs-H2-D1em4Dvs/Dvs |
| enhancer trap | A type of DNA construct containing a reporter gene sequence downstream of a promoter that is capable of integrating into random chromosomal locations in mouse. Integration of the enhancer trap near an enhancer allows the expression of a new mRNA encoding the reporter gene. The reporter gene is therefore expressed in the cells and developmental stages where the enhancer is active. | B6(129S4)-Et(cre/ERT2)4Rdav/J |
| F1 hybrid | First filial generation. The offspring of an outcross between two inbred strains. | (129X1/SvJ x 129S1/Sv)F1-Kitl+ |
| F2 hybrid | Second filial generation. The offspring of sister x brother matings between the progeny of an F1 hybrid cross. | (C57BL/6 x DBA/2)F2 |
| F3 hybrid | Third filial generation. The offspring of sister x brother matings between the progeny of an F2 hybrid cross. | (C3HeB/Fe x STOCK Frem2my)F3 |
| gene trap | A type of DNA construct containing a reporter gene sequence downstream of a splice acceptor site that is capable of integrating into random chromosomal locations in mouse. Integration of the gene trap into an intron allows the expression of a new mRNA containing one or more upstream exons followed by the reporter gene. The reporter gene is therefore expressed in the same cells and developmental stages as the gene into which the gene trap has inserted. | 129-Gt(ROSA)26Sor/J |
| inbred strain | A strain that is essentially homozygous at all loci. In mice, a strain produced from brother-sister matings for at least 20 sequential generations. | C57BL/6J |
| insertion | A type of mutation in which one or more nucleotides is inserted into a DNA sequence. | B6.Cg-Axin1Fu-Tg1/CosMmjax |
| inversion | A type of mutation in which a length of DNA is broken in two positions and repaired in such a way that the medial segment is now present in reverse order. Inversions range in size from those large enough to be visible cytogenetically to those involving only a few base pairs. | STOCK In(4)56Rk/J |
| major histocompatibility congenic | A congenic strain in which the donor allele transferred to the host strain background is a major histocompatibility gene. | B6.C-H2-Kbm1/By |
| minor histocompatibility congenic | A congenic strain in which the donor allele transferred to the host strain background is a minor histocompatibility gene. | B6.C-H21c/ByJ |
| Mixed cross | Crosses that don't fit other cross attributes or where some details of the cross are unknown. They may also be incipient inbred stocks or inbred strains that are derived from up to three parental strains (one of which could be a gene-targeted ES cell line). These stocks should not be assumed to be inbred unless accompanied by an inbreeding generation number greater than or equal to F20. | (C57BL/6 x C3H)F1 x BALB/c |
| non-inbred | A stock that is known to be not inbred, or intentionally kept to prevent it from becoming inbred. | Hsd:NMRI |
| other | Refers to a mouse, colony, or population to which no other Attribute applies. | STOCK PCS |
| outbred stock | Stocks that are genetically undefined; that is, no two individuals from an outbred stock are the same. Outbreds are intentionally not bred with siblings or close relatives, as the purpose of an outbred stock is to maintain maximum heterozygosity. | NMRI |
| QTL | Quantitative Trait Locus. A polymorphic locus has alleles that differentially affect the expression of a continuously distributed phenotypic trait. Usually, a QTL is a marker described by statistical association to quantitative variation in the particular phenotypic trait thought to be controlled by the cumulative action of alleles at multiple loci. | NOD.B6-(D17Mit114-D17Mit101)/Orl |
| radiation induced mutation | Exposure of mice to X-rays or other types of radiation results in germline transmissible mutations. | SB/LeJ |
| recombinant congenic (RC) | Strain formed by crossing two inbred strains, followed by a few backcrosses to one of the parental strains, with subsequent inbreeding without selection. | NONcNZO10/LtJ |
| recombinant inbred (RI) | Strain of mice started from a cross between two different inbred strains followed by inbreeding for at least 20 generations | BXD8/TyJ |
| revertant | An individual carrying an allele of a given gene that at one time produced a mutant phenotype, but which since has undergone a subsequent mutation that restored a wild-type phenotype. The mutation need not restore the gene to its original nucleotide sequence to be considered a reversion event. | C57BL/6NJ-Crb1rd8+em1Mvw/MvwJ |
| Robertsonian | A particular type of translocation in which the breakpoints in the two chromosomes occur at or near the centromere, followed by centric fusion such that the long arms now form a metacentric chromosome with a single centromere | C57BL/6J-Rb(6.18)2Dn/J |
| segregating inbred | Inbred stains in which a particular allele or mutation is maintained in the heterozygous state. They are developed by inbreeding (usually brother x sister mating) but with heterozygosity selected at each generation. | 129P3/J |
| spontaneous mutation | No laboratory manipulation took place to generate the mutations or mutant phenotypes. Phenotype annotations are to naturally occurring mutants displaying abnormal phenotypes. | C57BL/6J-KitW-v/J |
| strain family | Includes substrains and other related strains | 129 |
| targeted mutation | Targeted mutations are generated by the process of homologous recombination in stem cell lines at a specific genomic location. | B6.129S2-Trp53tm1Tyj/J |
| transgenic | Random integration of foreign DNA into the genome results in a germline transmissible mutation. | B6.Cg-Tg(SOD1*G93A)1Gur/J |
| translocation | A translocation is type of mutation in which two nonhomologous chromosomes are each broken and then repaired. | RBF/DnJ |
| transposition | A type of chromosome rearrangement in which a segment of a chromosome is moved to a different location on the same chromosome. | FVB/N-Del(1Sdccag8-Akt3)CA1C2Ove/J |
| trisomy | The condition of having three chromosomes of a particular type or 3 copies of a large portion of a chromosome. | B6EiC3Sn a/A-Ts(1716)65Dn/J |
| variant allele | Allelic variants are differences between alleles, detectable by any assay. For example, differences in anonymous DNA sequences can be detected as simple sequence length polymorphism (SSLP) or single nucleotide polymorphisms (SNPs). Other types of variants include differences in protein molecular weight or charge, differences in enzyme activity, or differences in single-stranded conformation (SSCP). | CByJ.SJL(B6)-Ptprca/J |
| wild | A mouse or population taken directly from the wild, i.e., not produced by breeding in captivity. | M. m. molossinus |
| wild-derived | A strain or stock descended from wild-caught progenitors. | CAST/EiJ |
| wild-type allele | One of many possible versions of a gene that functions normally, as opposed to versions of a gene that are functionally abnormal (i.e., mutant alleles). | C3Sn.BLiA-Pde6b+/DnJ |
Yes. You can filter your results by strain attribute. Above the table of your search results, click the button to Filter strains by Attribute, and then in the Filter pop-up window, check the attributes you wish to remain after filtering.