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Cisd3 Gene Detail
Summary
  • Symbol
    Cisd3
  • Name
    CDGSH iron sulfur domain 3
  • Synonyms
    Mel13
  • Feature Type
    protein coding gene
  • IDs
    MGI:101788
    NCBI Gene: 217149
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97576652-97579447 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101788
 protein coding gene Chr11:97576291-97579451 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026812
 protein coding gene Chr2:168197047-168197691 (-)
A/J MGP_AJ_G0026778
 protein coding gene Chr2:161453330-161454174 (-)
AKR/J MGP_AKRJ_G0026749
 protein coding gene Chr2:166209823-166210737 (-)
BALB/cJ MGP_BALBcJ_G0026787
 protein coding gene Chr2:161772366-161772970 (-)
C3H/HeJ MGP_C3HHeJ_G0026529
 protein coding gene Chr2:166559128-166559782 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019429
 protein coding gene Chr11:103231880-103235249 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017060
 protein coding gene Chr11:93463088-93465809 (+)
CAST/EiJ MGP_CASTEiJ_G0018344
 protein coding gene Chr11:99976047-99978844 (+)
CBA/J MGP_CBAJ_G0026506
 protein coding gene Chr2:179396010-179396634 (-)
DBA/2J MGP_DBA2J_G0026644
 protein coding gene Chr2:160620794-160621388 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0026747
 protein coding gene Chr2:168346464-168347088 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026632
 protein coding gene Chr2:183087786-183088340 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019469
 protein coding gene Chr11:99291043-99294686 (+)
PWK/PhJ MGP_PWKPhJ_G0018116
 protein coding gene Chr11:96544995-96547895 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017906
 protein coding gene Chr11:99009346-99012075 (+)
WSB/EiJ MGP_WSBEiJ_G0018394
 protein coding gene Chr11:99198258-99202455 (+)



Homology
more
  • Human Ortholog
    CISD3, CDGSH iron sulfur domain 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CISD3, CDGSH iron sulfur domain 3
  • Synonyms
    Miner2, MiNT
  • Links
    NCBI Gene ID: 284106
    neXtProt AC: NX_P0C7P0
    UniProt: P0C7P0

  • Chr Location
    17q12; chr17:38730341-38735605 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    47
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078695 Ensembl Gene Model | MGI Sequence Detail 2796 C57BL/6J ±  kb
transcript ENSMUST00000107583 Ensembl | MGI Sequence Detail 737 Not Applicable  
polypeptide ENSMUSP00000103209 Ensembl | MGI Sequence Detail 137 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030840 CDGSH iron-sulfur domain-containing protein 3, mitochondrial
    (term hierarchy)
  • InterPro Domains
    IPR052950 CDGSH iron-sulfur domain-containing protein
    IPR018967 Iron-binding zinc finger, CDGSH type
    IPR042216 MitoNEET, CDGSH iron-sulfur domain
  • GlyGen
    B1AR13 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 48
    Genomic 1
    cDNA 47

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-18596
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:15805 Haupt Y, et al., Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral insertion locus. Mol Biol Rep. 1992 Nov;17(1):17-20
  • Latest
    J:346350 Jiang H, et al., FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3. Int Immunopharmacol. 2023 Jan 24;116:109762
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory