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Lig1 Gene Detail
Summary
  • Symbol
    Lig1
  • Name
    ligase I, DNA, ATP-dependent
  • Synonyms
    LigI, mLigI
  • Feature Type
    protein coding gene
  • IDs
    MGI:101789
    NCBI Gene: 16881
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:13011239-13045350 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 7.82 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    911 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101789
 protein coding gene Chr7:13011101-13045351 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031671
 protein coding gene Chr7:10671256-10707697 (+)
A/J MGP_AJ_G0031645
 protein coding gene Chr7:10533641-10568664 (+)
AKR/J MGP_AKRJ_G0031568
 protein coding gene Chr7:10779795-10813106 (+)
BALB/cJ MGP_BALBcJ_G0031650
 protein coding gene Chr7:10617383-10651450 (+)
C3H/HeJ MGP_C3HHeJ_G0031371
 protein coding gene Chr7:10924682-10958644 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032114
 protein coding gene Chr7:11250726-11285636 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029205
 protein coding gene Chr7:12368629-12404596 (+)
CAST/EiJ MGP_CASTEiJ_G0030729
 protein coding gene Chr7:8394853-8433731 (+)
CBA/J MGP_CBAJ_G0031329
 protein coding gene Chr7:11451630-11488287 (+)
DBA/2J MGP_DBA2J_G0031487
 protein coding gene Chr7:10394323-10428333 (+)
FVB/NJ MGP_FVBNJ_G0031443
 protein coding gene Chr7:10418722-10454593 (+)
LP/J MGP_LPJ_G0031573
 protein coding gene Chr7:10781428-10816162 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031478
 protein coding gene Chr7:11537214-11572351 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032144
 protein coding gene Chr7:10547878-10584695 (+)
PWK/PhJ MGP_PWKPhJ_G0030457
 protein coding gene Chr7:8861922-8896267 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030283
 protein coding gene Chr7:6625472-6659336 (+)
WSB/EiJ MGP_WSBEiJ_G0030824
 protein coding gene Chr7:10584061-10620923 (+)



Homology
more
  • Human Ortholog
    LIG1, DNA ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIG1, DNA ligase 1
  • Synonyms
    hLig1, IMD96, LIGI
  • Links
    NCBI Gene ID: 3978
    neXtProt AC: NX_P18858
    UniProt: P18858

  • Chr Location
    19q13.33; chr19:48115445-48170603 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human LIG1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired fetal hematopoiesis, develop anemia, and die by E16.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    940
  • Tissues
    168
  • cDNA Data
    14
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      58
    • RefSeq
      6
    • UniProt
      6
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056394 Ensembl Gene Model | MGI Sequence Detail 34112 C57BL/6J ±  kb
    transcript ENSMUST00000177588 Ensembl | MGI Sequence Detail 3174 Not Applicable  
    polypeptide ENSMUSP00000136972 Ensembl | MGI Sequence Detail 916 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18597, MGI:2142100
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:19305 Savini E, et al., Cloning and sequence analysis of a cDNA coding for the murine DNA ligase I enzyme. Gene. 1994 Jul 8;144(2):253-7
    • Latest
      J:340875 Zhou Z, et al., Fance deficiency inhibits primordial germ cell proliferation associated with transcription-replication conflicts accumulate and DNA repair defects. J Ovarian Res. 2023 Aug 10;16(1):160
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory