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Dppa5a Gene Detail
Summary
  • Symbol
    Dppa5a
  • Name
    developmental pluripotency associated 5A
  • Synonyms
    Dppa5, ecat2, Esg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101800
    NCBI Gene: 434423
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:78274334-78275459 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101800
 protein coding gene Chr9:78274334-78275481 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035062
 protein coding gene Chr9:78737324-78738281 (+)
A/J MGP_AJ_G0035047
 protein coding gene Chr9:76141334-76148534 (-)
AKR/J MGP_AKRJ_G0034975
 protein coding gene Chr9:77949614-77950956 (-)
BALB/cJ MGP_BALBcJ_G0035035
 protein coding gene Chr9:75800748-75803746 (-)
C3H/HeJ MGP_C3HHeJ_G0034747
 protein coding gene Chr9:78467080-78468847 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035556
 protein coding gene Chr9:80987494-80989792 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032465
 protein coding gene Chr9:75381069-75382177 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0034720
 protein coding gene Chr9:83856019-83856832 (-)
DBA/2J MGP_DBA2J_G0034878
 protein coding gene Chr9:75786631-75787435 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0034863
 protein coding gene Chr9:85032395-85033119 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0033768
 protein coding gene Chr9:75932107-75948984 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033605
 protein coding gene Chr9:78309048-78309582 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DPPA5, developmental pluripotency associated 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPPA5, developmental pluripotency associated 5
  • Synonyms
    ESG1
  • Links
    NCBI Gene ID: 340168
    neXtProt AC: NX_A6NC42
    UniProt: A6NC42

  • Chr Location
    6q13; chr6:73353063-73354276 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
  • All Mutations and Alleles
    54
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    49
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Dppa5a
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    9 strains or lines available
Homozygous null mice exhibit normal development and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    923
  • Tissues
    99
  • cDNA Data
    15
  • Literature Summary
    20
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060461 Ensembl Gene Model | MGI Sequence Detail 1126 C57BL/6J ±  kb
transcript ENSMUST00000071991 Ensembl | MGI Sequence Detail 619 Not Applicable  
polypeptide ENSMUSP00000071881 Ensembl | MGI Sequence Detail 118 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 1
    cDNA 15
    Primer pair 5
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18610, MGI:2142955, MGI:2157526
References
more
  • Summaries
    All 54
    Developmental Gene Expression 20
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:292025 Gomez-Redondo I, et al., Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion. Int J Mol Sci. 2020 Jun 9;21(11):4115
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory