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Gys1 Gene Detail
Summary
  • Symbol
    Gys1
  • Name
    glycogen synthase 1, muscle
  • Synonyms
    Gys3, MGS
  • Feature Type
    protein coding gene
  • IDs
    MGI:101805
    NCBI Gene: 14936
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45084268-45106043 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    741 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101805
 protein coding gene Chr7:45084263-45106043 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032222
 protein coding gene Chr7:45690838-45719781 (+)
A/J MGP_AJ_G0032201
 protein coding gene Chr7:44821521-44843261 (+)
AKR/J MGP_AKRJ_G0032137
 protein coding gene Chr7:46064414-46087457 (+)
BALB/cJ MGP_BALBcJ_G0032213
 protein coding gene Chr7:44810494-44832377 (+)
C3H/HeJ MGP_C3HHeJ_G0031929
 protein coding gene Chr7:46543657-46569296 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032705
 protein coding gene Chr7:47961303-47989265 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029719
 protein coding gene Chr7:47371941-47391709 (+)
CAST/EiJ MGP_CASTEiJ_G0031257
 protein coding gene Chr7:37955435-37995555 (+)
CBA/J MGP_CBAJ_G0031893
 protein coding gene Chr7:49542465-49574316 (+)
DBA/2J MGP_DBA2J_G0032051
 protein coding gene Chr7:44483979-44506792 (+)
FVB/NJ MGP_FVBNJ_G0032002
 protein coding gene Chr7:44269565-44291106 (+)
LP/J MGP_LPJ_G0032129
 protein coding gene Chr7:46392099-46417812 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032039
 protein coding gene Chr7:48245015-48268723 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032721
 protein coding gene Chr7:45277283-45299694 (+)
PWK/PhJ MGP_PWKPhJ_G0030980
 protein coding gene Chr7:37858891-37883738 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030817
 protein coding gene Chr7:33285898-33307772 (+)
WSB/EiJ MGP_WSBEiJ_G0031374
 protein coding gene Chr7:45771946-45796023 (+)



Homology
more
  • Human Ortholog
    GYS1, glycogen synthase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GYS1, glycogen synthase 1
  • Synonyms
    GSY, GYS
  • Links
    NCBI Gene ID: 2997
    neXtProt AC: NX_P13807
    UniProt: P13807

  • Chr Location
    19q13.33; chr19:48968130-48993310 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GYS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 6 alleles in 8 genetic backgrounds
    7 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality due to impaired cardiac function and exhibit reduced reduced ventricular chamber size, dilated atria, vascular congestion, and liver hemorrhage. Mice homozygous for a knock-in allele show altered glycogen homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    111
  • cDNA Data
    101
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003865 Ensembl Gene Model | MGI Sequence Detail 21776 C57BL/6J ±  kb
    transcript ENSMUST00000003964 Ensembl | MGI Sequence Detail 3678 Not Applicable  
    polypeptide ENSMUSP00000003964 Ensembl | MGI Sequence Detail 738 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 108
      cDNA 105
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18617, MGD-MRK-35845, MGI:107378
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 17
      Gene Ontology 15
      Phenotypes 41
    • Earliest
      J:19730 Seldin MF, et al., Glycogen synthase: a putative locus for diet-induced hyperglycemia. J Clin Invest. 1994 Jul;94(1):269-76
    • Latest
      J:355075 Brewer MK, et al., Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2024 May;168(5):744-759
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory