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Ccser2 Gene Detail
Summary
  • Symbol
    Ccser2
  • Name
    coiled-coil serine rich 2
  • Synonyms
    1700012P13Rik, 2900054P12Rik, Gcap14
  • Feature Type
    protein coding gene
  • IDs
    MGI:101859
    NCBI Gene: 72972
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:36596893-36690734 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 21.29 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2658 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101859
 protein coding gene Chr14:36596893-36690762 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021183
 protein coding gene Chr14:30347801-30468920 (-)
A/J MGP_AJ_G0021131
 protein coding gene Chr14:29107125-29200411 (-)
AKR/J MGP_AKRJ_G0021108
 protein coding gene Chr14:30443505-30537560 (-)
BALB/cJ MGP_BALBcJ_G0021135
 protein coding gene Chr14:29336685-29430515 (-)
C3H/HeJ MGP_C3HHeJ_G0020918
 protein coding gene Chr14:30327338-30420847 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021567
 protein coding gene Chr14:31463088-31558849 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019129
 protein coding gene Chr14:29088978-29184947 (-)
CAST/EiJ MGP_CASTEiJ_G0020443
 protein coding gene Chr14:30195717-30308072 (-)
CBA/J MGP_CBAJ_G0020884
 protein coding gene Chr14:32625622-32726784 (-)
DBA/2J MGP_DBA2J_G0021007
 protein coding gene Chr14:29148836-29242112 (-)
FVB/NJ MGP_FVBNJ_G0020991
 protein coding gene Chr14:29127282-29221916 (-)
LP/J MGP_LPJ_G0021076
 protein coding gene Chr14:30658185-30759010 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021017
 protein coding gene Chr14:31846211-31945456 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021600
 protein coding gene Chr14:30291221-30400851 (-)
PWK/PhJ MGP_PWKPhJ_G0020191
 protein coding gene Chr14:28690258-28784957 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020015
 protein coding gene Chr14:29831655-29934592 (-)
WSB/EiJ MGP_WSBEiJ_G0020498
 protein coding gene Chr14:30326732-30422747 (-)



Homology
more
  • Human Ortholog
    CCSER2, coiled-coil serine rich protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCSER2, coiled-coil serine rich protein 2
  • Synonyms
    bA486O22.1, FAM190B, Gcap14, KIAA1128
  • Links
    NCBI Gene ID: 54462
    neXtProt AC: NX_Q9H7U1
    UniProt: Q9H7U1

  • Chr Location
    10q23.1; chr10:84328586-84518521 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality, impaired cortical lamination, and decreased neuronal migration with a decrease in the length without changing the orientation of the leading process.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    19
  • cDNA Data
    22
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058690 Ensembl Gene Model | MGI Sequence Detail 93842 C57BL/6J ±  kb
    transcript ENSMUST00000067700 Ensembl | MGI Sequence Detail 7334 Not Applicable  
    polypeptide ENSMUSP00000068550 Ensembl | MGI Sequence Detail 1038 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000031032 serine-rich coiled-coil domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR029627 Serine-rich coiled-coil domain-containing protein
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 22
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-18683, MGI:1916586, MGI:1920222, MGI:2145593, MGI:2145799
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
    • Latest
      J:333716 Mun DJ, et al., Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2214507120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory