Tead1 MGI Mouse Gene Detail - MGI:101876 - TEA domain family member 1

Symbol

Tead1
Name

TEA domain family member 1
Synonyms

2610024B07Rik, B230114H05Rik, Gtrgeo5, mTEF-1, Tcf13, TEAD-1, TEF-1

Feature Type

protein coding gene
IDs

MGI:101876
NCBI Gene: 21676
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr7:112278563-112505991 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 58.80 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

5525 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101876	protein coding gene	Chr7:112278525-112506014 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032871	protein coding gene	Chr7:116274489-116519391 (+)
A/J	MGP_AJ_G0032854	protein coding gene	Chr7:113360024-113588083 (+)
AKR/J	MGP_AKRJ_G0032786	protein coding gene	Chr7:116215938-116445956 (+)
BALB/cJ	MGP_BALBcJ_G0032859	protein coding gene	Chr7:113059422-113290139 (+)
C3H/HeJ	MGP_C3HHeJ_G0032569	protein coding gene	Chr7:116216409-116457868 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033365	protein coding gene	Chr7:120999269-121241755 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030337	protein coding gene	Chr7:114955840-115189895 (+)
CAST/EiJ	MGP_CASTEiJ_G0031897	protein coding gene	Chr7:107819397-108063923 (+)
CBA/J	MGP_CBAJ_G0032542	protein coding gene	Chr7:125002709-125245147 (+)
DBA/2J	MGP_DBA2J_G0032694	protein coding gene	Chr7:111442381-111672060 (+)
FVB/NJ	MGP_FVBNJ_G0032647	protein coding gene	Chr7:111288437-111521664 (+)
LP/J	MGP_LPJ_G0032788	protein coding gene	Chr7:117774516-118000066 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032679	protein coding gene	Chr7:126581749-126834691 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033385	protein coding gene	Chr7:115206149-115444043 (+)
PWK/PhJ	MGP_PWKPhJ_G0031604	protein coding gene	Chr7:104273249-104507023 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031452	protein coding gene	Chr7:101966265-102206083 (+)
WSB/EiJ	MGP_WSBEiJ_G0032010	protein coding gene	Chr7:116080772-116320954 (+)

Human Ortholog

TEAD1, TEA domain transcription factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEAD1, TEA domain transcription factor 1
Synonyms

AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1
Links

HGNC:11714

NCBI Gene ID: 7003

neXtProt AC: NX_P28347

UniProt: P28347
Chr Location

11p15.3; chr11:12674421-12944737 (+) GRCh38

MGI Vertebrate Homology

Tead1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TEAD1
Protein SuperFamily

TEF
Gene Tree

Tead1

Diseases

1 with human TEAD1 associations

				Human Disease	Mouse Models
				Sveinsson chorioretinal atrophy IDs Sveinsson chorioretinal atrophy DOID:0111228 MESH:C566236 OMIM:108985 ORDO:86813 UMLS_CUI:C1862382

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 4 alleles in 4 genetic backgrounds
27 phenotypes from multigenic genotypes
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

484
Endonuclease-mediated

2
Gene trapped

473
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

1 involving Tead1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

275 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die between embryonic day 11 and 12.5. Abnormalities were seen in heart development.

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All GO Annotations

56
GO References

23

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1026
Tissues

265
cDNA Data

29
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tead1

ZFIN tead1a

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All Sequences

90
RefSeq

6
UniProt

16
CCDS

CCDS52365.1, CCDS52366.1, CCDS52367.1

Ensembl

ENSMUSG00000055320 (Evidence)
NCBI Gene

21676

			Length	Strain/Species	Flank
genomic	21676	NCBI Gene Model \| MGI Sequence Detail	227429	C57BL/6J	± kb
transcript	NM_001166584	RefSeq \| MGI Sequence Detail	9905	C57BL/6
polypeptide	P30051	UniProt \| EBI \| MGI Sequence Detail	426	Not Applicable

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UniProt

16 Sequences
Protein Ontology

PR:000016218 transcriptional enhancer factor TEF-1

(term hierarchy)
InterPro Domains

IPR000818 TEA/ATTS domain

IPR038096 TEA/ATTS domain superfamily

IPR050937 TEC1/TEAD Transcription Factor

IPR016361 Transcriptional enhancer factor, metazoa

IPR041086 YAP binding domain

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All nucleic 38

cDNA 31

Primer pair 7

Microarray probesets 5

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MGD-MRK-18702, MGD-MRK-18736, MGI:1917551, MGI:2444852

Summaries

All 123

Developmental Gene Expression 34

Gene Ontology 23

Phenotypes 40
Earliest

J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
Latest

J:345955 Wu Y, et al., TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population. Diabetes Obes Metab. 2024 Feb 22;

TSS for Tead1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68581	Chr7:112278521-112278532 (+)	-36 bp
Tssr68582	Chr7:112278534-112278580 (+)	-6 bp
Tssr68583	Chr7:112278585-112278594 (+)	27 bp
Tssr68584	Chr7:112278608-112278629 (+)	56 bp
Tssr68585	Chr7:112278633-112278638 (+)	73 bp
Tssr68586	Chr7:112278650-112278673 (+)	99 bp
Tssr68587	Chr7:112281932-112281936 (+)	3,371 bp
Tssr68588	Chr7:112286429-112286432 (+)	7,868 bp
Tssr68589	Chr7:112341232-112341267 (+)	62,687 bp
Tssr68590	Chr7:112341277-112341287 (+)	62,719 bp
Tssr68591	Chr7:112354892-112354897 (+)	76,332 bp
Tssr2375	Chr7:112402130-112402132 (+)	123,568 bp
Tssr68592	Chr7:112409004-112409017 (+)	130,448 bp
Tssr68593	Chr7:112415330-112415339 (+)	136,772 bp
Tssr68594	Chr7:112452360-112452365 (+)	173,800 bp
Tssr68595	Chr7:112455805-112455820 (+)	177,250 bp
Tssr68596	Chr7:112455823-112455832 (+)	177,265 bp
Tssr68597	Chr7:112455838-112455843 (+)	177,278 bp
Tssr68598	Chr7:112498216-112498220 (+)	219,655 bp
Tssr68599	Chr7:112499147-112499160 (+)	220,591 bp
Tssr68600	Chr7:112504108-112504113 (+)	225,548 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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