Tcf12 MGI Mouse Gene Detail - MGI:101877 - transcription factor 12

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Tcf12 Gene Detail

Symbol

Tcf12
Name

transcription factor 12
Synonyms

ALF1, bHLHb20, HEB, HEBAlt, HTF-4, HTF4, ME1, REB

Feature Type

protein coding gene
IDs

MGI:101877
NCBI Gene: 21406
Alliance

gene page
Transcription Start Sites

27 TSS

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Sequence Map

Chr9:71751534-72019611 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 39.85 cM
Mapping Data

8 experiments

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SNPs within 2kb

4973 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_101877	protein coding gene	Chr9:71749970-72019611 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035012	protein coding gene	Chr9:71980518-72253045 (-)
A/J	MGP_AJ_G0034993	protein coding gene	Chr9:69463764-69728013 (-)
AKR/J	MGP_AKRJ_G0034922	protein coding gene	Chr9:71130169-71398641 (-)
BALB/cJ	MGP_BALBcJ_G0034985	protein coding gene	Chr9:69178675-69439803 (-)
C3H/HeJ	MGP_C3HHeJ_G0034694	protein coding gene	Chr9:71635356-71906431 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035504	protein coding gene	Chr9:73880144-74155285 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032415	protein coding gene	Chr9:68982362-69241246 (-)
CAST/EiJ	MGP_CASTEiJ_G0034016	protein coding gene	Chr9:71921623-72200086 (-)
CBA/J	MGP_CBAJ_G0034667	protein coding gene	Chr9:76444918-76727403 (-)
DBA/2J	MGP_DBA2J_G0034826	protein coding gene	Chr9:69192002-69455312 (-)
FVB/NJ	MGP_FVBNJ_G0034768	protein coding gene	Chr9:68511076-68773741 (-)
LP/J	MGP_LPJ_G0034907	protein coding gene	Chr9:72190968-72458388 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034809	protein coding gene	Chr9:77493002-77782306 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035526	protein coding gene	Chr9:71265622-71536917 (-)
PWK/PhJ	MGP_PWKPhJ_G0033720	protein coding gene	Chr9:69445467-69710301 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033553	protein coding gene	Chr9:71580786-71851311 (-)
WSB/EiJ	MGP_WSBEiJ_G0034128	protein coding gene	Chr9:71194974-71463828 (-)

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Human Ortholog

TCF12, transcription factor 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TCF12, transcription factor 12
Synonyms

bHLHb20, CRS3, HEB, HH26, HsT17266, HTF4, p64, TCF-12
Links

HGNC:11623

NCBI Gene ID: 6938

neXtProt AC: NX_Q99081

UniProt: Q99081
Chr Location

15q21.3; chr15:56918090-57299281 (+) GRCh38

MGI Vertebrate Homology

Tcf12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TCF12
Gene Tree

Tcf12

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Diseases

2 with human TCF12 associations

				Human Disease	Mouse Models
				craniosynostosis IDs craniosynostosis DOID:2340 ICD10CM:Q75.0 MESH:D003398 NCI:C84655 OMIM:123100 OMIM:182212 OMIM:600593 OMIM:600775 OMIM:604757 OMIM:615314 ORDO:1531 UMLS_CUI:C0010278
				hypogonadotropic hypogonadism IDs hypogonadotropic hypogonadism DOID:0090070 ICD10CM:E23.0 OMIM:PS147950 ORDO:432 ORDO:478

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 6 alleles in 8 genetic backgrounds
28 phenotypes from multigenic genotypes
58 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (ENU)

4
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

27
Targeted

4
Genomic Mutations

1 involving Tcf12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

75 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells.

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All GO Annotations

57
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1062
Tissues

267
cDNA Data

250
Literature Summary

41

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TCF12

Xenbase tcf12

ZFIN tcf12

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All Sequences

132
RefSeq

38
UniProt

19
CCDS

CCDS23329.1, CCDS72271.1, CCDS72272.1

Ensembl

ENSMUSG00000032228 (Evidence)
NCBI Gene

21406

Representative Sequences				Length	Strain/Species	Flank
	genomic	21406	NCBI Gene Model \| MGI Sequence Detail	268078	C57BL/6J	± kb
	transcript	NM_011544	RefSeq \| MGI Sequence Detail	4707	ZRU/MplStud
	polypeptide	Q61286	UniProt \| EBI \| MGI Sequence Detail	706	Not Applicable

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UniProt

19 Sequences
Protein Ontology

PR:000016176 transcription factor 12

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR051098 Neuronal Differentiation E-box Binding Transcription Factors
GlyGen

Q61286 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 260

Genomic 1

cDNA 251

Primer pair 6

Other 2

Microarray probesets 4

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MGD-MRK-18703

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Summaries

All 148

Developmental Gene Expression 41

Gene Ontology 14

Phenotypes 58
Earliest

J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
Latest

J:354589 Tousinas G, et al., Stabilization of beta-Catenin Directs HEB to Limit Thymic Selection. J Immunol. 2024 Sep 1;213(5):641-650

TSS for Tcf12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90481	Chr9:72019109-72019177 (-)	468 bp
Tssr90480	Chr9:72019037-72019099 (-)	543 bp
Tssr90479	Chr9:72018983-72018994 (-)	622 bp
Tssr90478	Chr9:72018454-72018507 (-)	1,130 bp
Tssr90477	Chr9:72018270-72018279 (-)	1,336 bp
Tssr90476	Chr9:72018155-72018198 (-)	1,434 bp
Tssr90475	Chr9:72018116-72018152 (-)	1,477 bp
Tssr90474	Chr9:72018102-72018113 (-)	1,503 bp
Tssr90473	Chr9:72006658-72006662 (-)	12,951 bp
Tssr90472	Chr9:71997676-71997680 (-)	21,933 bp
Tssr90471	Chr9:71997536-71997569 (-)	22,058 bp
Tssr90470	Chr9:71992030-71992034 (-)	27,579 bp
Tssr90469	Chr9:71984769-71984783 (-)	34,835 bp
Tssr90468	Chr9:71954357-71954363 (-)	65,251 bp
Tssr90467	Chr9:71942271-71942275 (-)	77,338 bp
Tssr90466	Chr9:71935787-71935791 (-)	83,822 bp
Tssr90465	Chr9:71924493-71924497 (-)	95,116 bp
Tssr90464	Chr9:71917754-71917758 (-)	101,855 bp
Tssr90463	Chr9:71915293-71915298 (-)	104,315 bp
Tssr90462	Chr9:71904532-71904542 (-)	115,074 bp
Tssr90461	Chr9:71903919-71903923 (-)	115,690 bp
Tssr90460	Chr9:71903586-71903589 (-)	116,023 bp
Tssr90459	Chr9:71883401-71883403 (-)	136,209 bp
Tssr90458	Chr9:71883257-71883262 (-)	136,351 bp
Tssr2932	Chr9:71803397-71803398 (-)	216,213 bp
Tssr90457	Chr9:71803385-71803390 (-)	216,223 bp
Tssr90456	Chr9:71803329-71803384 (-)	216,254 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24