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Pou5f1 Gene Detail
Summary
  • Symbol
    Pou5f1
  • Name
    POU domain, class 5, transcription factor 1
  • Synonyms
    Oct-3, Oct-3/4, Oct3/4, Oct-4, Oct4, Otf-3, Otf3, Otf3g, Otf3-rs7, Otf-4, Otf4
  • Feature Type
    protein coding gene
  • IDs
    MGI:101893
    NCBI Gene: 18999
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35816929-35821674 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.69 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101893
 protein coding gene Chr17:35816915-35821674 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023640
 protein coding gene Chr17:35674128-35679217 (+)
A/J MGP_AJ_G0023595
 protein coding gene Chr17:34577034-34581561 (+)
AKR/J MGP_AKRJ_G0023565
 protein coding gene Chr17:34979194-34984161 (+)
BALB/cJ MGP_BALBcJ_G0023600
 protein coding gene Chr17:34703959-34708487 (+)
C3H/HeJ MGP_C3HHeJ_G0023366
 protein coding gene Chr17:35447951-35452477 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024042
 protein coding gene Chr17:37138148-37142117 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021520
 protein coding gene Chr17:32277958-32282743 (+)
CAST/EiJ MGP_CASTEiJ_G0022857
 protein coding gene Chr17:35546625-35553035 (+)
CBA/J MGP_CBAJ_G0023344
 protein coding gene Chr17:38683563-38688090 (+)
DBA/2J MGP_DBA2J_G0023468
 protein coding gene Chr17:33891707-33896235 (+)
FVB/NJ MGP_FVBNJ_G0023439
 protein coding gene Chr17:33680286-33684829 (+)
LP/J MGP_LPJ_G0023548
 protein coding gene Chr17:36055138-36065496 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023460
 protein coding gene Chr17:37489530-37495285 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024085
 protein coding gene Chr17:35318596-35321326 (+)
PWK/PhJ MGP_PWKPhJ_G0022608
 protein coding gene Chr17:32742345-32748070 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022427
 protein coding gene Chr17:33350832-33358499 (+)
WSB/EiJ MGP_WSBEiJ_G0022923
 protein coding gene Chr17:35448392-35452917 (+)



Homology
more
  • Human Ortholog
    POU5F1, POU class 5 homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU5F1, POU class 5 homeobox 1
  • Synonyms
    Oct-3, OCT3, Oct3/4, Oct-4, OCT4, OTF-3, OTF3, OTF4
  • Links
    NCBI Gene ID: 5460
    neXtProt AC: NX_Q01860
    UniProt: Q01860

  • Chr Location
    6p21.33; chr6:31164337-31180731 (-)  GRCh38
  • Human Ortholog
    POU5F1B, POU class 5 homeobox 1B
  • Synonyms
    OCT4-PG1, OCT4PG1, OTF3C, OTF3P1, POU5F1P1, POU5F1P4, POU5FLC20, POU5FLC8
  • Links
    NCBI Gene ID: 5462
    neXtProt AC: NX_Q06416
    UniProt: Q06416

  • Chr Location
    8q24.21; chr8:127322183-127420066 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human POU5F1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 8 alleles in 10 genetic backgrounds
    22 phenotypes from multigenic genotypes
    131 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for a targeted null mutation results in peri-implantation lethality prior to the egg cylinder stage, associated with failure to develop a pluripotent inner cell mass. Conditional mutations show defects in reproduction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    131
  • GO References
    91
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2555
  • Tissues
    414
  • cDNA Data
    58
  • Literature Summary
    576
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18999 NCBI Gene Model | MGI Sequence Detail 4746 C57BL/6J ±  kb
    transcript NM_013633 RefSeq | MGI Sequence Detail 1353 ZRU/MplStud  
    polypeptide P20263 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 190
      Genomic 10
      cDNA 65
      Primer pair 69
      Other 46

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12976, MGD-MRK-12977, MGD-MRK-13063, MGD-MRK-13065, MGD-MRK-13070, MGD-MRK-13077, MGD-MRK-13080, MGD-MRK-18720, MGD-MRK-19416
    References
    more
    • Summaries
      All 914
      Developmental Gene Expression 576
      Gene Ontology 91
      Phenotypes 131
    • Earliest
      J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
    • Latest
      J:355681 Dias Mirandela M, et al., Two-factor authentication underpins the precision of the piRNA pathway. Nature. 2024 Oct;634(8035):979-985
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory