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F2rl1 Gene Detail
Summary
  • Symbol
    F2rl1
  • Name
    F2R like trypsin receptor 1
  • Synonyms
    coagulation factor II (thrombin) receptor-like 1, Gpcr11, Par2, PAR-2, Protease-activated receptor-2, proteinase-activated receptor-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101910
    NCBI Gene: 14063
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:95648240-95661735 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 49.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    566 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101910
 protein coding gene Chr13:95648226-95661748 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020842
 protein coding gene Chr13:96990993-97004164 (-)
A/J MGP_AJ_G0020796
 protein coding gene Chr13:93347955-93361602 (-)
AKR/J MGP_AKRJ_G0020770
 protein coding gene Chr13:96200775-96214980 (-)
BALB/cJ MGP_BALBcJ_G0020793
 protein coding gene Chr13:94025920-94039081 (-)
C3H/HeJ MGP_C3HHeJ_G0020586
 protein coding gene Chr13:95892997-95906164 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021229
 protein coding gene Chr13:99932203-99945684 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018798
 protein coding gene Chr13:89176860-89190802 (-)
CAST/EiJ MGP_CASTEiJ_G0020105
 protein coding gene Chr13:95195567-95209777 (-)
CBA/J MGP_CBAJ_G0020545
 protein coding gene Chr13:103904655-103917824 (-)
DBA/2J MGP_DBA2J_G0020670
 protein coding gene Chr13:93124958-93138029 (-)
FVB/NJ MGP_FVBNJ_G0020651
 protein coding gene Chr13:91909476-91922736 (-)
LP/J MGP_LPJ_G0020745
 protein coding gene Chr13:97099955-97113124 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020679
 protein coding gene Chr13:104336307-104349776 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021269
 protein coding gene Chr13:95593354-95607291 (-)
PWK/PhJ MGP_PWKPhJ_G0019857
 protein coding gene Chr13:91907117-91920687 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019681
 protein coding gene Chr13:91887367-91900591 (-)
WSB/EiJ MGP_WSBEiJ_G0020162
 protein coding gene Chr13:96103436-96116564 (-)



Homology
more
  • Human Ortholog
    F2RL1, F2R like trypsin receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F2RL1, F2R like trypsin receptor 1
  • Synonyms
    GPR11, PAR2
  • Links
    NCBI Gene ID: 2150
    neXtProt AC: NX_P55085
    UniProt: P55085

  • Chr Location
    5q13.3; chr5:76818933-76835315 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human F2RL1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 6 alleles in 9 genetic backgrounds
    24 phenotypes from multigenic genotypes
    165 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice may exhibit impaired leukocyte rolling and dendritic cell maturation, altered inflammatory response in various models of acute and chronic inflammatory disease, altered susceptibility to injury and to autoimmune disorders, and abnormal hemodynamic responses and pain thresholds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    111
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    75
  • cDNA Data
    25
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021678 Ensembl Gene Model | MGI Sequence Detail 13496 C57BL/6J ±  kb
    transcript ENSMUST00000022185 Ensembl | MGI Sequence Detail 2741 Not Applicable  
    polypeptide ENSMUSP00000022185 Ensembl | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 6
      cDNA 25
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18739
    References
    more
    • Summaries
      All 249
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 15
      Phenotypes 165
    • Earliest
      J:20517 Nystedt S, et al., Molecular cloning of a potential proteinase activated receptor [see comments]. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9208-12
    • Latest
      J:351032 Nakazawa M, et al., Protective role of protease-activated receptor-2 in anaphylaxis model mice. PLoS One. 2024;19(4):e0283915
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory