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Arhgdib Gene Detail
Summary
  • Symbol
    Arhgdib
  • Name
    Rho, GDP dissociation inhibitor beta
  • Synonyms
    D4, Gdid4, Ly-GDI
  • Feature Type
    protein coding gene
  • IDs
    MGI:101940
    NCBI Gene: 11857
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:136900653-136918895 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 66.72 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    666 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101940
 protein coding gene Chr6:136900653-136918897 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031432
 protein coding gene Chr6:141437476-141457095 (-)
A/J MGP_AJ_G0031407
 protein coding gene Chr6:135819310-135837704 (-)
AKR/J MGP_AKRJ_G0031335
 protein coding gene Chr6:139953501-139973166 (-)
BALB/cJ MGP_BALBcJ_G0031414
 protein coding gene Chr6:135698021-135716666 (-)
C3H/HeJ MGP_C3HHeJ_G0031136
 protein coding gene Chr6:139984743-140004117 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031876
 protein coding gene Chr6:145268300-145289392 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029006
 protein coding gene Chr6:134933705-134951421 (-)
CAST/EiJ MGP_CASTEiJ_G0030504
 protein coding gene Chr6:139496896-139516381 (-)
CBA/J MGP_CBAJ_G0031096
 protein coding gene Chr6:150710854-150732749 (-)
DBA/2J MGP_DBA2J_G0031253
 protein coding gene Chr6:134693864-134718143 (-)
FVB/NJ MGP_FVBNJ_G0031204
 protein coding gene Chr6:133593820-133615317 (-)
LP/J MGP_LPJ_G0031337
 protein coding gene Chr6:141541102-141561737 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031244
 protein coding gene Chr6:154591710-154611321 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031908
 protein coding gene Chr6:139697872-139718303 (-)
PWK/PhJ MGP_PWKPhJ_G0030231
 protein coding gene Chr6:133191578-133210444 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030055
 protein coding gene Chr6:137959722-137989778 (-)
WSB/EiJ MGP_WSBEiJ_G0030597
 protein coding gene Chr6:140339334-140360917 (-)



Homology
more
  • Human Ortholog
    ARHGDIB, Rho GDP dissociation inhibitor beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGDIB, Rho GDP dissociation inhibitor beta
  • Synonyms
    D4, GDIA2, GDID4, Ly-GDI, LYGDI, RAP1GN1, RhoGDI2
  • Links
    NCBI Gene ID: 397
    neXtProt AC: NX_P52566
    UniProt: P52566

  • Chr Location
    12p12.3; chr12:14942015-14961728 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A homozygous null mutation results in mice that are viable and fertile. Immune responses are similar to controls in mice, but in vitro analysis demonstrated an increased B cell proliferative response upon lectin stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    24
  • cDNA Data
    78
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11857 NCBI Gene Model | MGI Sequence Detail 18243 C57BL/6J ±  kb
transcript NM_001409500 RefSeq | MGI Sequence Detail 1562 C57BL/6  
polypeptide Q61599 UniProt | EBI | MGI Sequence Detail 200 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    Genomic 1
    cDNA 79

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18774
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:18526 Adra CN, et al., Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I. Genes Chromosomes Cancer. 1993 Dec;8(4):253-61
  • Latest
    J:235379 Yavari A, et al., Chronic Activation of gamma2 AMPK Induces Obesity and Reduces beta Cell Function. Cell Metab. 2016 May 10;23(5):821-36
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory