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Crisp1 Gene Detail
Summary
  • Symbol
    Crisp1
  • Name
    cysteine-rich secretory protein 1
  • Synonyms
    Aeg1, CRISP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102553
    NCBI Gene: 11571
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:40604649-40630098 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.47 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    837 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102553
 protein coding gene Chr17:40604649-40630098 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023753
 protein coding gene Chr17:41089442-41117744 (-)
A/J MGP_AJ_G0023711
 protein coding gene Chr17:40162510-40188616 (-)
AKR/J MGP_AKRJ_G0023683
 protein coding gene Chr17:40247775-40292162 (-)
BALB/cJ MGP_BALBcJ_G0023714
 protein coding gene Chr17:40030954-40056682 (-)
C3H/HeJ MGP_C3HHeJ_G0023480
 protein coding gene Chr17:40862784-40883344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024157
 protein coding gene Chr17:42909279-42932566 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021611
 protein coding gene Chr17:37129490-37326678 (-)
CAST/EiJ MGP_CASTEiJ_G0022960
 protein coding gene Chr17:41024667-41050829 (-)
CBA/J MGP_CBAJ_G0023456
 protein coding gene Chr17:44394335-44440964 (-)
DBA/2J MGP_DBA2J_G0023581
 protein coding gene Chr17:38974531-38996701 (-)
FVB/NJ MGP_FVBNJ_G0023548
 protein coding gene Chr17:38567377-38608101 (-)
LP/J MGP_LPJ_G0023662
 protein coding gene Chr17:41708598-41736199 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023576
 protein coding gene Chr17:43771863-43823790 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024203
 protein coding gene Chr17:40638399-40660579 (-)
PWK/PhJ MGP_PWKPhJ_G0022704
 protein coding gene Chr17:38327207-38350002 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022522
 protein coding gene Chr17:37801864-37825644 (-)
WSB/EiJ MGP_WSBEiJ_G0023025
 protein coding gene Chr17:41049074-41105497 (-)



Homology
more
  • Human Ortholog
    CRISP3, cysteine rich secretory protein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRISP3, cysteine rich secretory protein 3
  • Synonyms
    Aeg2, CRISP-3, CRS3, dJ442L6.3, SGP28
  • Links
    NCBI Gene ID: 10321
    neXtProt AC: NX_P54108
    UniProt: P54108

  • Chr Location
    6p12.3; chr6:49727376-49744437 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced ability of sperm to fertilize eggs but no reduction in fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    6
  • cDNA Data
    18
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11571 NCBI Gene Model | MGI Sequence Detail 25450 C57BL/6J ±  kb
transcript NM_009638 RefSeq | MGI Sequence Detail 1416 ZRU/MplStud  
polypeptide Q03401 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 4
    cDNA 18
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-19402, MGI:2147060
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:3169 Mizuki N, et al., Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule. Mol Cell Endocrinol. 1992 Nov;89(1-2):25-32
  • Latest
    J:311209 Gaikwad AS, et al., CRISPs Function to Boost Sperm Power Output and Motility. Front Cell Dev Biol. 2021;9:693258
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory