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Dct Gene Detail
Summary
  • Symbol
    Dct
  • Name
    dopachrome tautomerase
  • Synonyms
    TRP-2, TRP2, tyrosinase-related protein-2, Tyrp-2, Tyrp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102563
    NCBI Gene: 13190
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:118250202-118289656 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 61.60 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1467 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102563
 protein coding gene Chr14:118250202-118289658 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021646
 protein coding gene Chr14:115567053-115608002 (-)
A/J MGP_AJ_G0021605
 protein coding gene Chr14:111169920-111209200 (-)
AKR/J MGP_AKRJ_G0021581
 protein coding gene Chr14:114774297-114817417 (-)
BALB/cJ MGP_BALBcJ_G0021611
 protein coding gene Chr14:111712094-111751540 (-)
C3H/HeJ MGP_C3HHeJ_G0021389
 protein coding gene Chr14:114658128-114699858 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022051
 protein coding gene Chr14:120053269-120099941 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019590
 protein coding gene Chr14:107241479-107281770 (-)
CAST/EiJ MGP_CASTEiJ_G0020905
 protein coding gene Chr14:112488452-112527802 (-)
CBA/J MGP_CBAJ_G0021357
 protein coding gene Chr14:124667292-124710278 (-)
DBA/2J MGP_DBA2J_G0021480
 protein coding gene Chr14:111091624-111131026 (-)
FVB/NJ MGP_FVBNJ_G0021458
 protein coding gene Chr14:109427086-109467418 (-)
LP/J MGP_LPJ_G0021548
 protein coding gene Chr14:116607487-116647986 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021485
 protein coding gene Chr14:129752223-129793559 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022074
 protein coding gene Chr14:114236312-114276408 (-)
PWK/PhJ MGP_PWKPhJ_G0020649
 protein coding gene Chr14:108077074-108118932 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020487
 protein coding gene Chr14:110481465-110525879 (-)
WSB/EiJ MGP_WSBEiJ_G0020960
 protein coding gene Chr14:115041242-115083023 (-)



Homology
more
  • Human Ortholog
    DCT, dopachrome tautomerase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCT, dopachrome tautomerase
  • Synonyms
    OCA8, TRP-2, TYRP2
  • Links
    NCBI Gene ID: 1638
    neXtProt AC: NX_P40126
    UniProt: P40126

  • Chr Location
    13q32.1; chr13:94436811-94549406 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DCT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 8 alleles in 8 genetic backgrounds
    8 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this melanocyte protein gene cause coat color dilution.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1372
  • Tissues
    256
  • cDNA Data
    77
  • Literature Summary
    124
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022129 Ensembl Gene Model | MGI Sequence Detail 39455 C57BL/6J ±  kb
    transcript ENSMUST00000022725 Ensembl | MGI Sequence Detail 2202 Not Applicable  
    polypeptide ENSMUSP00000022725 Ensembl | MGI Sequence Detail 517 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      Genomic 4
      cDNA 80
      Primer pair 3
      Other 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14444, MGD-MRK-15317, MGD-MRK-15318, MGD-MRK-19444
    References
    more
    • Summaries
      All 229
      Developmental Gene Expression 124
      Gene Ontology 15
      Phenotypes 44
    • Earliest
      J:9222 Jackson IJ, A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse [published erratum appears in Proc Natl Acad Sci U S A 1989 Feb;86(3):997]. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4392-6
    • Latest
      J:355488 Erjavec E, et al., Congenital microcoria deletion in mouse links Sox21 dysregulation to disease and suggests a role for TGFB2 in glaucoma and myopia. Am J Hum Genet. 2024 Oct 3;111(10):2265-2282
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory