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Ptprf Gene Detail
Summary
  • Symbol
    Ptprf
  • Name
    protein tyrosine phosphatase receptor type F
  • Synonyms
    LAR, RPTP-LAR
  • Feature Type
    protein coding gene
  • IDs
    MGI:102695
    NCBI Gene: 19268
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118065410-118148602 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 54.47 cM, cytoband C6-D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1808 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102695
 protein coding gene Chr4:118065410-118148602 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028664
 protein coding gene Chr4:119236170-119322906 (-)
A/J MGP_AJ_G0028625
 protein coding gene Chr4:114629060-114712187 (-)
AKR/J MGP_AKRJ_G0028575
 protein coding gene Chr4:117135444-117218643 (-)
BALB/cJ MGP_BALBcJ_G0028646
 protein coding gene Chr4:115261954-115345266 (-)
C3H/HeJ MGP_C3HHeJ_G0028360
 protein coding gene Chr4:118707798-118791448 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029087
 protein coding gene Chr4:123811555-123897816 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026371
 protein coding gene Chr4:108650730-108733815 (-)
CAST/EiJ MGP_CASTEiJ_G0027794
 protein coding gene Chr4:115959058-116042904 (-)
CBA/J MGP_CBAJ_G0028327
 protein coding gene Chr4:127199274-127286252 (-)
DBA/2J MGP_DBA2J_G0028475
 protein coding gene Chr4:115238220-115321620 (-)
FVB/NJ MGP_FVBNJ_G0028443
 protein coding gene Chr4:113755951-113841126 (-)
LP/J MGP_LPJ_G0028577
 protein coding gene Chr4:119420636-119504662 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028470
 protein coding gene Chr4:132105226-132190472 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029124
 protein coding gene Chr4:118294769-118377817 (-)
PWK/PhJ MGP_PWKPhJ_G0027520
 protein coding gene Chr4:112068226-112152658 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027343
 protein coding gene Chr4:114594599-114678869 (-)
WSB/EiJ MGP_WSBEiJ_G0027873
 protein coding gene Chr4:118173686-118264361 (-)



Homology
more
  • Human Ortholog
    PTPRF, protein tyrosine phosphatase receptor type F
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRF, protein tyrosine phosphatase receptor type F
  • Synonyms
    BNAH2, LAR
  • Links
    NCBI Gene ID: 5792
    neXtProt AC: NX_P10586
    UniProt: P10586

  • Chr Location
    1p34.2; chr1:43522051-43623666 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PTPRF associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 4 genetic backgrounds
    42 phenotypes from multigenic genotypes
    5 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null females have premature involution of the mammary glands leading to an inability to feed pups. Other characteristics of null mice include defective nerve regeneration and hyperactivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    31
  • cDNA Data
    23
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19268 NCBI Gene Model | MGI Sequence Detail 83193 C57BL/6J ±  kb
    transcript NM_011213 RefSeq | MGI Sequence Detail 7648 C57BL/6  
    polypeptide A2A8L5 UniProt | EBI | MGI Sequence Detail 1898 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 2
      cDNA 23
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19599, MGI:2140169
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 12
      Phenotypes 40
    • Earliest
      J:14647 Streuli M, et al., A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen. J Exp Med. 1988 Nov 1;168(5):1523-30
    • Latest
      J:358058 Emperador-Melero J, et al., Distinct active zone protein machineries mediate Ca(2+) channel clustering and vesicle priming at hippocampal synapses. Nat Neurosci. 2024 Sep;27(9):1680-1694
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory