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Gng3 Gene Detail
Summary
  • Symbol
    Gng3
  • Name
    guanine nucleotide binding protein (G protein), gamma 3
  • Synonyms
    83
  • Feature Type
    protein coding gene
  • IDs
    MGI:102704
    NCBI Gene: 14704
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8814297-8816558 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.76 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102704
 protein coding gene Chr19:8814293-8816610 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024813
 protein coding gene Chr19:6119943-6122260 (-)
A/J MGP_AJ_G0024781
 protein coding gene Chr19:5789464-5791779 (-)
AKR/J MGP_AKRJ_G0024756
 protein coding gene Chr19:5881552-5883869 (-)
BALB/cJ MGP_BALBcJ_G0024781
 protein coding gene Chr19:5894562-5896882 (-)
C3H/HeJ MGP_C3HHeJ_G0024547
 protein coding gene Chr19:5961447-5963754 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025228
 protein coding gene Chr19:6248930-6251247 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022657
 protein coding gene Chr19:6038009-6040284 (-)
CAST/EiJ MGP_CASTEiJ_G0024020
 protein coding gene Chr19:5612456-5614760 (-)
CBA/J MGP_CBAJ_G0024521
 protein coding gene Chr19:6358784-6361094 (-)
DBA/2J MGP_DBA2J_G0024648
 protein coding gene Chr19:5622021-5624340 (-)
FVB/NJ MGP_FVBNJ_G0024615
 protein coding gene Chr19:5694622-5696939 (-)
LP/J MGP_LPJ_G0024735
 protein coding gene Chr19:6008245-6010566 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024642
 protein coding gene Chr19:6224791-6227102 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025277
 protein coding gene Chr19:5924566-5926883 (-)
PWK/PhJ MGP_PWKPhJ_G0023765
 protein coding gene Chr19:5290595-5292898 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023570
 protein coding gene Chr19:5535818-5538325 (-)
WSB/EiJ MGP_WSBEiJ_G0024082
 protein coding gene Chr19:5894589-5896911 (-)



Homology
more
  • Human Ortholog
    GNG3, G protein subunit gamma 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNG3, G protein subunit gamma 3
  • Synonyms
    HG3D
  • Links
    NCBI Gene ID: 2785
    neXtProt AC: NX_P63215
    UniProt: P63215

  • Chr Location
    11q12.3; chr11:62706446-62709201 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display handling- and noise-induced seizures resulting in premature death and reduced growth. Female homozygotes also display reduced inguinal and retroperitoneal fat pads.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    890
  • Tissues
    53
  • cDNA Data
    66
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071658 Ensembl Gene Model | MGI Sequence Detail 2262 C57BL/6J ±  kb
    transcript ENSMUST00000096259 Ensembl | MGI Sequence Detail 1643 Not Applicable  
    polypeptide ENSMUSP00000093978 Ensembl | MGI Sequence Detail 75 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008108 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
      (term hierarchy)
    • InterPro Domains
      IPR015898 G-protein gamma-like domain
      IPR036284 G-protein gamma-like domain superfamily
      IPR001770 G-protein, gamma subunit
    • GlyGen
      P63216 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 3
      cDNA 66
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-19608
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:14657 Gautam N, et al., G protein diversity is increased by associations with a variety of gamma subunits. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7973-7
    • Latest
      J:354049 Pulcrano S, et al., miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network. J Neurosci. 2023 Nov 29;43(48):8104-8125
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory