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Ddx3x Gene Detail
Summary
  • Symbol
    Ddx3x
  • Name
    DEAD box helicase 3, X-linked
  • Synonyms
    D1Pas1-rs2, Ddx3, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked, embryonic RNA helicase, Fin14
  • Feature Type
    protein coding gene
  • IDs
    MGI:103064
    NCBI Gene: 13205
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:13147261-13160222 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 8.17 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103064
 protein coding gene ChrX:13147209-13160291 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035571
 protein coding gene ChrX:8141733-8156270 (+)
A/J MGP_AJ_G0035549
 protein coding gene ChrX:8219824-8235521 (+)
AKR/J MGP_AKRJ_G0035481
 protein coding gene ChrX:8485195-8497392 (+)
BALB/cJ MGP_BALBcJ_G0035542
 protein coding gene ChrX:8086970-8101028 (+)
C3H/HeJ MGP_C3HHeJ_G0035258
 protein coding gene ChrX:8247368-8263313 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036071
 protein coding gene ChrX:8335889-8349080 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032941
 protein coding gene ChrX:7114832-7128273 (+)
CAST/EiJ MGP_CASTEiJ_G0034550
 protein coding gene ChrX:7975143-7989102 (+)
CBA/J MGP_CBAJ_G0035227
 protein coding gene ChrX:8770684-8784937 (+)
DBA/2J MGP_DBA2J_G0035380
 protein coding gene ChrX:8063136-8076212 (+)
FVB/NJ MGP_FVBNJ_G0035327
 protein coding gene ChrX:7902824-7915405 (+)
LP/J MGP_LPJ_G0035462
 protein coding gene ChrX:8325539-8338621 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035370
 protein coding gene ChrX:8684442-8697886 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036083
 protein coding gene ChrX:8057099-8068876 (+)
PWK/PhJ MGP_PWKPhJ_G0034251
 protein coding gene ChrX:7552190-7565397 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034092
 protein coding gene ChrX:8149888-8161029 (+)
WSB/EiJ MGP_WSBEiJ_G0034686
 protein coding gene ChrX:8097845-8109612 (+)



Homology
more
  • Human Ortholog
    DDX3X, DEAD-box helicase 3 X-linked
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX3X, DEAD-box helicase 3 X-linked
  • Synonyms
    CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102, MRXSSB
  • Links
    NCBI Gene ID: 1654
    neXtProt AC: NX_O00571
    UniProt: O00571

  • Chr Location
    Xp11.4; chrX:41333308-41364472 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DDX3X associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous males and heterozygous females with a maternally inherited null allele show early embryonic and fetal lethality, respectively. Both males and females show defects in trophoblast giant cells. Females show defects in placental formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    164
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    191
  • cDNA Data
    806
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13205 NCBI Gene Model | MGI Sequence Detail 12962 C57BL/6J ±  kb
    transcript NM_010028 RefSeq | MGI Sequence Detail 4571 ZRU/MplStud  
    polypeptide Q62167 UniProt | EBI | MGI Sequence Detail 662 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006364 ATP-dependent RNA helicase DDX3X
      (term hierarchy)
    • EC
      3.6.4.13
    • InterPro Domains
      IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
      IPR011545 DEAD/DEAH box helicase domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR014014 RNA helicase, DEAD-box type, Q motif
    • GlyGen
      Q62167 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 815
      cDNA 807
      Primer pair 6
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16302, MGD-MRK-23926, MGD-MRK-33748, MGI:106064, MGI:99525
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 20
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:17429 Gee SL, et al., Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals. Gene. 1994 Mar 25;140(2):171-7
    • Latest
      J:356773 Jowhar Z, et al., A ubiquitous GC content signature underlies multimodal mRNA regulation by DDX3X. Mol Syst Biol. 2024 Mar;20(3):276-290
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory