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Cox6a1 Gene Detail
Summary
  • Symbol
    Cox6a1
  • Name
    cytochrome c oxidase subunit 6A1
  • Synonyms
    subunit VIaL (liver-type), VIaL
  • Feature Type
    protein coding gene
  • IDs
    MGI:103099
    NCBI Gene: 12861
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115483711-115487017 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.06 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103099
 protein coding gene Chr5:115483701-115487040 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029968
 protein coding gene Chr5:118196595-118200884 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0029871
 protein coding gene Chr5:117152530-117155866 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0029663
 protein coding gene Chr5:117651306-117655023 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030398
 protein coding gene Chr5:122760620-122764767 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027625
 protein coding gene Chr5:108286997-108291146 (-)
CAST/EiJ MGP_CASTEiJ_G0029072
 protein coding gene Chr5:116574703-116578034 (-)
CBA/J MGP_CBAJ_G0029631
 protein coding gene Chr5:127476650-127479992 (-)
DBA/2J MGP_DBA2J_G0029781
 protein coding gene Chr5:113584518-113588765 (-)
FVB/NJ MGP_FVBNJ_G0029737
 protein coding gene Chr5:112402712-112406643 (-)
LP/J MGP_LPJ_G0029869
 protein coding gene Chr5:118770897-118774198 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029768
 protein coding gene Chr5:131792001-131796395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030439
 protein coding gene Chr5:116611682-116615973 (-)
PWK/PhJ MGP_PWKPhJ_G0028785
 protein coding gene Chr5:112246722-112250213 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028623
 protein coding gene Chr5:114174199-114177469 (-)
WSB/EiJ MGP_WSBEiJ_G0029147
 protein coding gene Chr5:117209830-117213109 (-)



Homology
more
  • Human Ortholog
    COX6A1, cytochrome c oxidase subunit 6A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX6A1, cytochrome c oxidase subunit 6A1
  • Synonyms
    CMTRID, COX6A, COX6AL
  • Links
    NCBI Gene ID: 1337
    neXtProt AC: NX_P12074
    UniProt: P12074

  • Chr Location
    12q24.2; chr12:120438090-120440737 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cox6a1 mouse models; 1 with human COX6A1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit impaired coordination, thinned sciatic nerves, neurogenic muscular changes and delayed motor nerve conduction velocity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    94
  • cDNA Data
    360
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12861 NCBI Gene Model | MGI Sequence Detail 3307 C57BL/6J ±  kb
    transcript NM_007748 RefSeq | MGI Sequence Detail 538 ZRU/MplStud  
    polypeptide P43024 UniProt | EBI | MGI Sequence Detail 111 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005781 cytochrome c oxidase subunit 6A1, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR001349 Cytochrome c oxidase, subunit VIa
      IPR018507 Cytochrome c oxidase, subunit VIa, conserved site
      IPR036418 Cytochrome c oxidase, subunit VIa superfamily
    • GlyGen
      P43024 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 362
      cDNA 361
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23963
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory