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Uimc1 Gene Detail
Summary
  • Symbol
    Uimc1
  • Name
    ubiquitin interaction motif containing 1
  • Synonyms
    9430016E08Rik, D330018D10Rik, D630032M02Rik, Rxrip110
  • Feature Type
    protein coding gene
  • IDs
    MGI:103185
    NCBI Gene: 20184
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55175693-55248113 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 29.80 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1462 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103185
 protein coding gene Chr13:55175693-55248176 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020584
 protein coding gene Chr13:54463884-54547912 (-)
A/J MGP_AJ_G0020538
 protein coding gene Chr13:52466922-52544425 (-)
AKR/J MGP_AKRJ_G0020516
 protein coding gene Chr13:54003652-54082678 (-)
BALB/cJ MGP_BALBcJ_G0020534
 protein coding gene Chr13:52697015-52777928 (-)
C3H/HeJ MGP_C3HHeJ_G0020333
 protein coding gene Chr13:53822413-53907896 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020968
 protein coding gene Chr13:56127983-56210543 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018550
 protein coding gene Chr13:50441068-50509525 (-)
CAST/EiJ MGP_CASTEiJ_G0019847
 protein coding gene Chr13:53914631-54001772 (-)
CBA/J MGP_CBAJ_G0020293
 protein coding gene Chr13:58256379-58344388 (-)
DBA/2J MGP_DBA2J_G0020416
 protein coding gene Chr13:52022081-52099530 (-)
FVB/NJ MGP_FVBNJ_G0020395
 protein coding gene Chr13:51486690-51562314 (-)
LP/J MGP_LPJ_G0020492
 protein coding gene Chr13:54738751-54822099 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020424
 protein coding gene Chr13:57759069-57845087 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021011
 protein coding gene Chr13:53591595-53669868 (-)
PWK/PhJ MGP_PWKPhJ_G0019603
 protein coding gene Chr13:52017421-52115241 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019430
 protein coding gene Chr13:52525357-52597163 (-)
WSB/EiJ MGP_WSBEiJ_G0019909
 protein coding gene Chr13:53935223-54021970 (-)



Homology
more
  • Human Ortholog
    UIMC1, ubiquitin interaction motif containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UIMC1, ubiquitin interaction motif containing 1
  • Synonyms
    RAP80, X2HRIP110
  • Links
    NCBI Gene ID: 51720
    neXtProt AC: NX_Q96RL1
    UniProt: Q96RL1

  • Chr Location
    5q35.2; chr5:176905005-177022633 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit premature death due to B-cell lymphomas and abnormal DNA repair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    84
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025878 Ensembl Gene Model | MGI Sequence Detail 72421 C57BL/6J ±  kb
    transcript ENSMUST00000127195 Ensembl | MGI Sequence Detail 2936 Not Applicable  
    polypeptide ENSMUSP00000122196 Ensembl | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      cDNA 86

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24053, MGI:1924548, MGI:2443168, MGI:2443285
    References
    more
    • Summaries
      All 46
      Diseases 1
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345315 Jiang Q, et al., Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition. J Cell Biol. 2022 Sep 5;221(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory