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Meox1 Gene Detail
Summary
  • Symbol
    Meox1
  • Name
    mesenchyme homeobox 1
  • Synonyms
    D330041M02Rik, Mox-1, Mox1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103220
    NCBI Gene: 17285
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101768336-101785200 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, Syntenic
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    654 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103220
 protein coding gene Chr11:101768336-101785309 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019213
 protein coding gene Chr11:104807383-104827204 (-)
A/J MGP_AJ_G0019181
 protein coding gene Chr11:100387941-100404807 (-)
AKR/J MGP_AKRJ_G0019150
 protein coding gene Chr11:103499549-103516401 (-)
BALB/cJ MGP_BALBcJ_G0019155
 protein coding gene Chr11:100870111-100887404 (-)
C3H/HeJ MGP_C3HHeJ_G0018964
 protein coding gene Chr11:103702759-103720830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019604
 protein coding gene Chr11:108084646-108102347 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017230
 protein coding gene Chr11:97808380-97826582 (-)
CAST/EiJ MGP_CASTEiJ_G0018518
 protein coding gene Chr11:104655342-104675075 (-)
CBA/J MGP_CBAJ_G0018933
 protein coding gene Chr11:112532737-112551417 (-)
DBA/2J MGP_DBA2J_G0019045
 protein coding gene Chr11:99910179-99928492 (-)
FVB/NJ MGP_FVBNJ_G0019035
 protein coding gene Chr11:99439466-99456555 (-)
LP/J MGP_LPJ_G0019114
 protein coding gene Chr11:105328742-105346818 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019066
 protein coding gene Chr11:112077140-112095173 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019642
 protein coding gene Chr11:103850050-103869446 (-)
PWK/PhJ MGP_PWKPhJ_G0018281
 protein coding gene Chr11:100964217-100983287 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018073
 protein coding gene Chr11:103590340-103609806 (-)
WSB/EiJ MGP_WSBEiJ_G0018567
 protein coding gene Chr11:103835560-103855058 (-)



Homology
more
  • Human Ortholog
    MEOX1, mesenchyme homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEOX1, mesenchyme homeobox 1
  • Synonyms
    KFS2, MOX1
  • Links
    NCBI Gene ID: 4222
    neXtProt AC: NX_P50221
    UniProt: P50221

  • Chr Location
    17q21.31; chr17:43640389-43661922 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MEOX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotypes from multigenic genotypes
    1 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit hemi-vertebrae, and rib, vertebral, and cranial-vertebral fusions, but are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1168
  • Tissues
    199
  • cDNA Data
    29
  • Literature Summary
    166
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001493 Ensembl Gene Model | MGI Sequence Detail 16865 C57BL/6J ±  kb
    transcript ENSMUST00000057054 Ensembl | MGI Sequence Detail 2228 Not Applicable  
    polypeptide ENSMUSP00000051158 Ensembl | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 1
      cDNA 31
      Primer pair 10
      Other 19

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12394, MGD-MRK-12396, MGD-MRK-24090, MGI:2144139, MGI:5749420
    References
    more
    • Summaries
      All 224
      Developmental Gene Expression 166
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:3682 Candia AF, et al., Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
    • Latest
      J:355651 El Azhar Y, et al., Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking. Development. 2024 Sep 15;151(18):dev202936
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory