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Inpp5b Gene Detail
Summary
  • Symbol
    Inpp5b
  • Name
    inositol polyphosphate-5-phosphatase B
  • Synonyms
    75kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:103257
    NCBI Gene: 16330
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124635643-124695304 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.89 cM, cytoband D2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1750 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103257
 protein coding gene Chr4:124635620-124695304 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028753
 protein coding gene Chr4:126288037-126354997 (+)
A/J MGP_AJ_G0028712
 protein coding gene Chr4:121338272-121397252 (+)
AKR/J MGP_AKRJ_G0028665
 protein coding gene Chr4:124643420-124714561 (+)
BALB/cJ MGP_BALBcJ_G0028735
 protein coding gene Chr4:121913612-121973225 (+)
C3H/HeJ MGP_C3HHeJ_G0028449
 protein coding gene Chr4:124746610-124811078 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029177
 protein coding gene Chr4:131160570-131220831 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026450
 protein coding gene Chr4:114510095-114572864 (+)
CAST/EiJ MGP_CASTEiJ_G0027882
 protein coding gene Chr4:122804713-122868132 (+)
CBA/J MGP_CBAJ_G0028415
 protein coding gene Chr4:134412310-134477281 (+)
DBA/2J MGP_DBA2J_G0028564
 protein coding gene Chr4:121815390-121875150 (+)
FVB/NJ MGP_FVBNJ_G0028531
 protein coding gene Chr4:120438153-120500955 (+)
LP/J MGP_LPJ_G0028665
 protein coding gene Chr4:126592952-126654361 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028557
 protein coding gene Chr4:139413663-139475248 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029215
 protein coding gene Chr4:125020604-125084229 (+)
PWK/PhJ MGP_PWKPhJ_G0027603
 protein coding gene Chr4:118228740-118293624 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027429
 protein coding gene Chr4:120793531-120855832 (+)
WSB/EiJ MGP_WSBEiJ_G0027962
 protein coding gene Chr4:125094907-125157588 (+)



Homology
more
  • Human Ortholog
    INPP5B, inositol polyphosphate-5-phosphatase B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INPP5B, inositol polyphosphate-5-phosphatase B
  • Synonyms
    5PTase
  • Links
    NCBI Gene ID: 3633
    neXtProt AC: NX_P32019
    UniProt: P32019

  • Chr Location
    1p34.3; chr1:37860697-37947057 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null male mice are infertile with a disruption in spermatogenesis and a defect in adherens junctions processing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    109
  • cDNA Data
    97
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028894 Ensembl Gene Model | MGI Sequence Detail 59662 C57BL/6J ±  kb
    transcript ENSMUST00000094782 Ensembl | MGI Sequence Detail 3809 Not Applicable  
    polypeptide ENSMUSP00000092375 Ensembl | MGI Sequence Detail 993 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 1
      cDNA 98
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24133, MGI:2140565
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:17529 Janne PA, et al., Localization of the 75-kDa inositol polyphosphate-5-phosphatase (INPP5B) to human chromosome band 1p34. Cytogenet Cell Genet. 1994;66(3):164-6
    • Latest
      J:336347 Wang B, et al., OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring. EMBO Rep. 2021 May 13;:e52173
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory