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Cacnb3 Gene Detail
Summary
  • Symbol
    Cacnb3
  • Name
    calcium channel, voltage-dependent, beta 3 subunit
  • Synonyms
    Beta3, Cchb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:103307
    NCBI Gene: 12297
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98528721-98542410 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 54.64 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103307
 protein coding gene Chr15:98526317-98542410 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022304
 protein coding gene Chr15:100379741-100392414 (+)
A/J MGP_AJ_G0022262
 protein coding gene Chr15:96413755-96427989 (+)
AKR/J MGP_AKRJ_G0022237
 protein coding gene Chr15:99382867-99396959 (+)
BALB/cJ MGP_BALBcJ_G0022269
 protein coding gene Chr15:96612171-96625191 (+)
C3H/HeJ MGP_C3HHeJ_G0022037
 protein coding gene Chr15:99424211-99437532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022714
 protein coding gene Chr15:104098192-104110638 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020239
 protein coding gene Chr15:92332865-92345089 (+)
CAST/EiJ MGP_CASTEiJ_G0021560
 protein coding gene Chr15:100280240-100292319 (+)
CBA/J MGP_CBAJ_G0022006
 protein coding gene Chr15:107629462-107644864 (+)
DBA/2J MGP_DBA2J_G0022132
 protein coding gene Chr15:95858743-95871047 (+)
FVB/NJ MGP_FVBNJ_G0022112
 protein coding gene Chr15:94835664-94849194 (+)
LP/J MGP_LPJ_G0022204
 protein coding gene Chr15:100530841-100543668 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022132
 protein coding gene Chr15:111656311-111669837 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022729
 protein coding gene Chr15:99460942-99475306 (+)
PWK/PhJ MGP_PWKPhJ_G0021301
 protein coding gene Chr15:95977379-95990687 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021136
 protein coding gene Chr15:99307322-99319079 (+)
WSB/EiJ MGP_WSBEiJ_G0021610
 protein coding gene Chr15:100007793-100020731 (+)



Homology
more
  • Human Ortholog
    CACNB3, calcium voltage-gated channel auxiliary subunit beta 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACNB3, calcium voltage-gated channel auxiliary subunit beta 3
  • Synonyms
    CAB3, CACNLB3
  • Links
    NCBI Gene ID: 784
    neXtProt AC: NX_P54284
    UniProt: P54284

  • Chr Location
    12q13.12; chr12:48813794-48828941 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show altered Ca2+ channel activity, hyporesponsiveness to DHP, high blood pressure on a high salt diet, and impaired calcium responses and cytokine production in CD4 T cells. Homozygotes for another null allele show enhancedNMDA activity and long term potentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    70
  • cDNA Data
    101
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003352 Ensembl Gene Model | MGI Sequence Detail 13690 C57BL/6J ±  kb
    transcript ENSMUST00000230490 Ensembl | MGI Sequence Detail 2477 Not Applicable  
    polypeptide ENSMUSP00000155514 Ensembl | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000004948 voltage-dependent L-type calcium channel subunit beta-3
      (term hierarchy)
    • InterPro Domains
      IPR008145 Guanylate kinase/L-type calcium channel beta subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR001452 SH3 domain
      IPR036028 SH3-like domain superfamily
      IPR008079 Voltage-dependent calcium channel, L-type, beta-3 subunit
      IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
      IPR046937 Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain
      IPR035760 Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain
    • GlyGen
      P54285 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 4
      cDNA 102
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24191
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 8
      Phenotypes 46
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory