About   Help   FAQ
Nova2 Gene Detail
Summary
  • Symbol
    Nova2
  • Name
    NOVA alternative splicing regulator 2
  • Synonyms
    LOC384569
  • Feature Type
    protein coding gene
  • IDs
    MGI:104296
    NCBI Gene: 384569
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:18659813-18699244 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    948 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104296
 protein coding gene Chr7:18659319-18699244 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031748
 protein coding gene Chr7:16859358-16904586 (+)
A/J MGP_AJ_G0031724
 protein coding gene Chr7:16562517-16601351 (+)
AKR/J MGP_AKRJ_G0031650
 protein coding gene Chr7:17012277-17053203 (+)
BALB/cJ MGP_BALBcJ_G0031729
 protein coding gene Chr7:16766412-16797727 (+)
C3H/HeJ MGP_C3HHeJ_G0031451
 protein coding gene Chr7:17265052-17311801 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032195
 protein coding gene Chr7:17751347-17791106 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029261
 protein coding gene Chr7:18228086-18250653 (+)
CAST/EiJ MGP_CASTEiJ_G0030794
 protein coding gene Chr7:13674429-13719134 (+)
CBA/J MGP_CBAJ_G0031413
 protein coding gene Chr7:18384104-18433215 (+)
DBA/2J MGP_DBA2J_G0031568
 protein coding gene Chr7:16498414-16538042 (+)
FVB/NJ MGP_FVBNJ_G0031520
 protein coding gene Chr7:16357732-16396438 (+)
LP/J MGP_LPJ_G0031651
 protein coding gene Chr7:17205236-17248436 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031556
 protein coding gene Chr7:18247160-18294275 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032223
 protein coding gene Chr7:16619385-16659252 (+)
PWK/PhJ MGP_PWKPhJ_G0030518
 protein coding gene Chr7:13581587-13621694 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030345
 protein coding gene Chr7:11302184-11350098 (+)
WSB/EiJ MGP_WSBEiJ_G0030894
 protein coding gene Chr7:16816795-16861430 (+)



Homology
more
  • Human Ortholog
    NOVA2, NOVA alternative splicing regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOVA2, NOVA alternative splicing regulator 2
  • Synonyms
    ANOVA, NEDASB, NOVA-2, NOVA3
  • Links
    NCBI Gene ID: 4858
    neXtProt AC: NX_Q9UNW9
    UniProt: Q9UNW9

  • Chr Location
    19q13.32; chr19:45933734-45974044 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in postnatal lethality, abolished long term potentiation of the small inhibitory postsynaptic current but not the excitatory postsynaptic current, and no pairing-induced potentiation of small inhibitory postsynatpic currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    957
  • Tissues
    93
  • cDNA Data
    37
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030411 Ensembl Gene Model | MGI Sequence Detail 39432 C57BL/6J ±  kb
transcript ENSMUST00000032571 Ensembl | MGI Sequence Detail 8372 Not Applicable  
polypeptide ENSMUSP00000032571 Ensembl | MGI Sequence Detail 556 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011340 RNA-binding protein Nova-2
    (term hierarchy)
  • InterPro Domains
    IPR004087 K Homology domain
    IPR004088 K Homology domain, type 1
    IPR036612 K Homology domain, type 1 superfamily
    IPR047275 RNA-binding protein Nova-1/2, type I K Homology domain 1
    IPR047276 RNA-binding protein Nova-1/2, type I K Homology domain 2
    IPR047274 RNA-binding protein Nova-1/2, type I K Homology domain 3
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-25623, MGI:2686270
References
more
  • Summaries
    All 48
    Developmental Gene Expression 10
    Gene Ontology 14
    Phenotypes 15
  • Earliest
    J:50542 Yang YY, et al., The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13254-9
  • Latest
    J:359186 Ibrahim LA, et al., Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing. Elife. 2023 Jun 22;12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory