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Nqo2 Gene Detail
Summary
  • Symbol
    Nqo2
  • Name
    N-ribosyldihydronicotinamide quinone reductase 2
  • Synonyms
    Nmor2, NRH: quinone oxidoreductase, Ox-2, Ox2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104513
    NCBI Gene: 18105
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:34148670-34172426 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 14.01 cM, cytoband A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    738 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104513
 protein coding gene Chr13:34148642-34172448 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020444
 protein coding gene Chr13:32066553-32091300 (+)
A/J MGP_AJ_G0020399
 protein coding gene Chr13:31125312-31149413 (+)
AKR/J MGP_AKRJ_G0020376
 protein coding gene Chr13:31860259-31886260 (+)
BALB/cJ MGP_BALBcJ_G0020394
 protein coding gene Chr13:31202071-31225995 (+)
C3H/HeJ MGP_C3HHeJ_G0020193
 protein coding gene Chr13:31792016-31815414 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020828
 protein coding gene Chr13:33132277-33160145 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018415
 protein coding gene Chr13:29440539-29463575 (+)
CAST/EiJ MGP_CASTEiJ_G0019709
 protein coding gene Chr13:31449861-31473920 (+)
CBA/J MGP_CBAJ_G0020153
 protein coding gene Chr13:34577525-34604108 (+)
DBA/2J MGP_DBA2J_G0020275
 protein coding gene Chr13:30650379-30681029 (+)
FVB/NJ MGP_FVBNJ_G0020255
 protein coding gene Chr13:30230389-30257201 (+)
LP/J MGP_LPJ_G0020351
 protein coding gene Chr13:32294036-32319535 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020286
 protein coding gene Chr13:34796481-34824891 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020871
 protein coding gene Chr13:31518513-31547160 (+)
PWK/PhJ MGP_PWKPhJ_G0019464
 protein coding gene Chr13:30766656-30795998 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019289
 protein coding gene Chr13:30170921-30193095 (+)
WSB/EiJ MGP_WSBEiJ_G0019771
 protein coding gene Chr13:31877699-31903890 (+)



Homology
more
  • Human Ortholog
    NQO2, N-ribosyldihydronicotinamide:quinone dehydrogenase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NQO2, N-ribosyldihydronicotinamide:quinone dehydrogenase 2
  • Synonyms
    DHQV, DIA6, NMOR2, QR2
  • Links
    NCBI Gene ID: 4835
    neXtProt AC: NX_P16083
    UniProt: P16083

  • Chr Location
    6p25.2; chr6:2987987-3019755 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human NQO2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygouse for disruptions in this gene have an essentially normal phenotype but with abnormalities in WBC counts and increased susceptibility to chemically induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    1
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046949 Ensembl Gene Model | MGI Sequence Detail 23757 C57BL/6J ±  kb
transcript ENSMUST00000058978 Ensembl | MGI Sequence Detail 3842 Not Applicable  
polypeptide ENSMUSP00000053809 Ensembl | MGI Sequence Detail 231 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13091, MGD-MRK-13093, MGD-MRK-25944
References
more
  • Summaries
    All 55
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:343492 Janda E, et al., Autophagy and neuroprotection in astrocytes exposed to 6-hydroxydopamine is negatively regulated by NQO2: relevance to Parkinson's disease. Sci Rep. 2023 Dec 7;13(1):21624
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory