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Gcdh Gene Detail
Summary
  • Symbol
    Gcdh
  • Name
    glutaryl-Coenzyme A dehydrogenase
  • Synonyms
    D17825
  • Feature Type
    protein coding gene
  • IDs
    MGI:104541
    NCBI Gene: 270076
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85613022-85620550 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.28 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104541
 protein coding gene Chr8:85613016-85629378 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033877
 protein coding gene Chr8:85813632-85821695 (-)
A/J MGP_AJ_G0033860
 protein coding gene Chr8:82432449-82439176 (-)
AKR/J MGP_AKRJ_G0033786
 protein coding gene Chr8:84874087-84881254 (-)
BALB/cJ MGP_BALBcJ_G0033853
 protein coding gene Chr8:82559764-82567095 (-)
C3H/HeJ MGP_C3HHeJ_G0033563
 protein coding gene Chr8:85498397-85506580 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034373
 protein coding gene Chr8:89094663-89102166 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031314
 protein coding gene Chr8:76226126-76233242 (-)
CAST/EiJ MGP_CASTEiJ_G0032893
 protein coding gene Chr8:84922653-84929987 (-)
CBA/J MGP_CBAJ_G0033539
 protein coding gene Chr8:92133535-92140971 (-)
DBA/2J MGP_DBA2J_G0033692
 protein coding gene Chr8:82071897-82079264 (-)
FVB/NJ MGP_FVBNJ_G0033640
 protein coding gene Chr8:81015663-81022831 (-)
LP/J MGP_LPJ_G0033784
 protein coding gene Chr8:85921033-85929347 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033682
 protein coding gene Chr8:94690519-94697246 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034390
 protein coding gene Chr8:84862412-84869232 (-)
PWK/PhJ MGP_PWKPhJ_G0032597
 protein coding gene Chr8:81318231-81325410 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032433
 protein coding gene Chr8:83672782-83683666 (-)
WSB/EiJ MGP_WSBEiJ_G0033006
 protein coding gene Chr8:85295484-85302830 (-)



Homology
more
  • Human Ortholog
    GCDH, glutaryl-CoA dehydrogenase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCDH, glutaryl-CoA dehydrogenase
  • Synonyms
    ACAD5, GCD
  • Links
    NCBI Gene ID: 2639
    neXtProt AC: NX_Q92947
    UniProt: Q92947

  • Chr Location
    19p13.13; chr19:12891128-12915126 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gcdh mouse models; 1 with human GCDH associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a mild motor deficit associated with a diffuse spongiform myelinopathy and elevated levels of glutaric acid and 3-hydroxyglutaric acid.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    47
  • cDNA Data
    81
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003809 Ensembl Gene Model | MGI Sequence Detail 7529 C57BL/6J ±  kb
    transcript ENSMUST00000003907 Ensembl | MGI Sequence Detail 2167 Not Applicable  
    polypeptide ENSMUSP00000003907 Ensembl | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000007888 glutaryl-CoA dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.3.8.6
    • InterPro Domains
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
      IPR052033 Mitochondrial Glutaryl-CoA Dehydrogenase
    • GlyGen
      Q60759 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 5
      cDNA 81
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-25973, MGI:2142490, MGI:2142887
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 12
      Phenotypes 65
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory