About   Help   FAQ
Procr Gene Detail
Summary
  • Symbol
    Procr
  • Name
    protein C receptor, endothelial
  • Synonyms
    Ccca, EPCR
  • Feature Type
    protein coding gene
  • IDs
    MGI:104596
    NCBI Gene: 19124
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:155593037-155597391 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.26 cM, cytoband H1-3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104596
 protein coding gene Chr2:155592159-155597391 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026742
 protein coding gene Chr2:160589400-160593703 (+)
A/J MGP_AJ_G0026708
 protein coding gene Chr2:154211862-154216260 (+)
AKR/J MGP_AKRJ_G0026679
 protein coding gene Chr2:158699153-158703507 (+)
BALB/cJ MGP_BALBcJ_G0026717
 protein coding gene Chr2:154509936-154514285 (+)
C3H/HeJ MGP_C3HHeJ_G0026460
 protein coding gene Chr2:159046905-159051214 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027166
 protein coding gene Chr2:165297804-165302148 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024536
 protein coding gene Chr2:147704181-147708493 (+)
CAST/EiJ MGP_CASTEiJ_G0025921
 protein coding gene Chr2:159363248-159367562 (+)
CBA/J MGP_CBAJ_G0026437
 protein coding gene Chr2:171302279-171306586 (+)
DBA/2J MGP_DBA2J_G0026574
 protein coding gene Chr2:153394511-153398847 (+)
FVB/NJ MGP_FVBNJ_G0026541
 protein coding gene Chr2:151769417-151773731 (+)
LP/J MGP_LPJ_G0026679
 protein coding gene Chr2:160734995-160739295 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026562
 protein coding gene Chr2:175293783-175298092 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027222
 protein coding gene Chr2:158565559-158569868 (+)
PWK/PhJ MGP_PWKPhJ_G0025655
 protein coding gene Chr2:152891834-152896266 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025458
 protein coding gene Chr2:157506745-157511043 (+)
WSB/EiJ MGP_WSBEiJ_G0025991
 protein coding gene Chr2:159456775-159461085 (+)



Homology
more
  • Human Ortholog
    PROCR, protein C receptor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROCR, protein C receptor
  • Synonyms
    CCCA, CCD41, EPCR
  • Links
    NCBI Gene ID: 10544
    neXtProt AC: NX_Q9UNN8
    UniProt: Q9UNN8

  • Chr Location
    20q11.22; chr20:35171096-35216259 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 7 alleles in 11 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous embryos die by E10.5 showing placental thrombosis, small size, and incomplete turning. Mice with a severe deficiency survive and reproduce normally. Homozygotes for the R84A variant show increased thrombin formation after thrombotic and LPS challenge, splenomegaly, and bone marrow failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    86
  • cDNA Data
    41
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027611 Ensembl Gene Model | MGI Sequence Detail 4355 C57BL/6J ±  kb
    transcript ENSMUST00000029140 Ensembl | MGI Sequence Detail 1597 Not Applicable  
    polypeptide ENSMUSP00000029140 Ensembl | MGI Sequence Detail 242 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000001347 endothelial protein C receptor
      (term hierarchy)
    • InterPro Domains
      IPR015669 Endothelial protein C receptor
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR011161 MHC class I-like antigen recognition-like
      IPR037055 MHC class I-like antigen recognition-like superfamily
    • GlyGen
      Q64695 5 sites, 2 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 41
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24087, MGD-MRK-26030, MGI:2138904
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 55
    • Earliest
      J:22114 Rothbarth K, et al., cDNA-derived molecular characteristics and antibodies to a new centrosome-associated and G2/M phase-prevalent protein. J Cell Sci. 1993 Jan;104(Pt 1):19-30
    • Latest
      J:354658 Chen Q, et al., Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice. Blood. 2024 Aug 1;144(5):552-564
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory