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Wars1 Gene Detail
Summary
  • Symbol
    Wars1
  • Name
    tryptophanyl-tRNA synthetase1
  • Synonyms
    Wars
  • Feature Type
    protein coding gene
  • IDs
    MGI:104630
    NCBI Gene: 22375
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108825956-108860095 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 59.66 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    908 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104630
 protein coding gene Chr12:108825956-108860100 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020111
 protein coding gene Chr12:111020753-111055813 (-)
A/J MGP_AJ_G0020065
 protein coding gene Chr12:106797600-106833660 (-)
AKR/J MGP_AKRJ_G0020041
 protein coding gene Chr12:109895012-109931005 (-)
BALB/cJ MGP_BALBcJ_G0020051
 protein coding gene Chr12:107220676-107254636 (-)
C3H/HeJ MGP_C3HHeJ_G0019853
 protein coding gene Chr12:110343796-110378969 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020496
 protein coding gene Chr12:114435691-114470339 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018108
 protein coding gene Chr12:103315367-103355454 (-)
CAST/EiJ MGP_CASTEiJ_G0019395
 protein coding gene Chr12:105288087-105323246 (-)
CBA/J MGP_CBAJ_G0019820
 protein coding gene Chr12:119000617-119034686 (-)
DBA/2J MGP_DBA2J_G0019937
 protein coding gene Chr12:106335048-106370359 (-)
FVB/NJ MGP_FVBNJ_G0019922
 protein coding gene Chr12:105121648-105161144 (-)
LP/J MGP_LPJ_G0020012
 protein coding gene Chr12:110883698-110919092 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019960
 protein coding gene Chr12:122139405-122174448 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020525
 protein coding gene Chr12:109380417-109415346 (-)
PWK/PhJ MGP_PWKPhJ_G0019154
 protein coding gene Chr12:100957422-100992262 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018958
 protein coding gene Chr12:103586456-103620423 (-)
WSB/EiJ MGP_WSBEiJ_G0019452
 protein coding gene Chr12:110318651-110353472 (-)



Homology
more
  • Human Ortholog
    WARS1, tryptophanyl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WARS1, tryptophanyl-tRNA synthetase 1
  • Synonyms
    GAMMA-2, HMN9, HMND9, IFI53, IFP53, NEDMSBA, WARS
  • Links
    NCBI Gene ID: 7453
    neXtProt AC: NX_P23381
    UniProt: P23381

  • Chr Location
    14q32.2; chr14:100333790-100376805 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human WARS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    135
  • cDNA Data
    211
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22375 NCBI Gene Model | MGI Sequence Detail 34140 C57BL/6J ±  kb
    transcript NM_001164314 RefSeq | MGI Sequence Detail 2798 C57BL/6  
    polypeptide P32921 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 214
      cDNA 212
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-26067, MGI:7280669
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:20958 Pajot B, et al., An alternative splicing modifies the C-terminal end of tryptophanyl-tRNA synthetase in murine embryonic stem cells. J Mol Biol. 1994 Sep 30;242(4):599-603
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory