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Tle2 Gene Detail
Summary
  • Symbol
    Tle2
  • Name
    transducin-like enhancer of split 2
  • Synonyms
    Grg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104635
    NCBI Gene: 21886
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81410395-81426679 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    372 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104635
 protein coding gene Chr10:81410395-81435018 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017566
 protein coding gene Chr10:82306304-82322668 (+)
A/J MGP_AJ_G0017544
 protein coding gene Chr10:79381647-79397931 (+)
AKR/J MGP_AKRJ_G0017505
 protein coding gene Chr10:81557077-81573360 (+)
BALB/cJ MGP_BALBcJ_G0017506
 protein coding gene Chr10:79606572-79622877 (+)
C3H/HeJ MGP_C3HHeJ_G0017329
 protein coding gene Chr10:81666439-81682686 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017960
 protein coding gene Chr10:85124722-85145085 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015649
 protein coding gene Chr10:75577676-75593833 (+)
CAST/EiJ MGP_CASTEiJ_G0016896
 protein coding gene Chr10:81910707-81927073 (+)
CBA/J MGP_CBAJ_G0017301
 protein coding gene Chr10:88472877-88489161 (+)
DBA/2J MGP_DBA2J_G0017407
 protein coding gene Chr10:78585957-78602199 (+)
FVB/NJ MGP_FVBNJ_G0017401
 protein coding gene Chr10:77855060-77871307 (+)
LP/J MGP_LPJ_G0017478
 protein coding gene Chr10:82756824-82774802 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017427
 protein coding gene Chr10:90292676-90310188 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018001
 protein coding gene Chr10:81577304-81593906 (+)
PWK/PhJ MGP_PWKPhJ_G0016677
 protein coding gene Chr10:78492442-78508760 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016467
 protein coding gene Chr10:80522722-80538945 (+)
WSB/EiJ MGP_WSBEiJ_G0016956
 protein coding gene Chr10:81624470-81640752 (+)



Homology
more
  • Human Ortholog
    TLE2, TLE family member 2, transcriptional corepressor
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLE2, TLE family member 2, transcriptional corepressor
  • Synonyms
    ESG, ESG2, GRG2
  • Links
    NCBI Gene ID: 7089
    neXtProt AC: NX_Q04725
    UniProt: Q04725

  • Chr Location
    19p13.3; chr19:2997639-3047635 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from multigenic genotypes
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    993
  • Tissues
    136
  • cDNA Data
    41
  • Literature Summary
    20
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034771 Ensembl Gene Model | MGI Sequence Detail 16285 C57BL/6J ±  kb
transcript ENSMUST00000146358 Ensembl | MGI Sequence Detail 2749 Not Applicable  
polypeptide ENSMUSP00000121125 Ensembl | MGI Sequence Detail 767 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 41
    Primer pair 3
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-26072
References
more
  • Summaries
    All 58
    Developmental Gene Expression 20
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:343425 Andreani C, et al., SIRT6 promotes metastasis and relapse in HER2-positive breast cancer. Sci Rep. 2023 Dec 12;13(1):22000
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory