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Cnr2 Gene Detail
Summary
  • Symbol
    Cnr2
  • Name
    cannabinoid receptor 2
  • Synonyms
    cannabinoid receptor 2 (spleen), CB2, CB2-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:104650
    NCBI Gene: 12802
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135622705-135647518 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    740 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104650
 protein coding gene Chr4:135622500-135647530 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028952
 protein coding gene Chr4:138389677-138414570 (+)
A/J MGP_AJ_G0028911
 protein coding gene Chr4:132512618-132538154 (+)
AKR/J MGP_AKRJ_G0028863
 protein coding gene Chr4:136334023-136360176 (+)
BALB/cJ MGP_BALBcJ_G0028935
 protein coding gene Chr4:133184138-133208766 (+)
C3H/HeJ MGP_C3HHeJ_G0028649
 protein coding gene Chr4:136618732-136645322 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029376
 protein coding gene Chr4:143295067-143320859 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026647
 protein coding gene Chr4:125565318-125588568 (+)
CAST/EiJ MGP_CASTEiJ_G0028081
 protein coding gene Chr4:134748354-134776142 (+)
CBA/J MGP_CBAJ_G0028614
 protein coding gene Chr4:147227548-147256135 (+)
DBA/2J MGP_DBA2J_G0028763
 protein coding gene Chr4:132945971-132970891 (+)
FVB/NJ MGP_FVBNJ_G0028730
 protein coding gene Chr4:131863786-131889181 (+)
LP/J MGP_LPJ_G0028862
 protein coding gene Chr4:138488302-138513482 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028756
 protein coding gene Chr4:151509016-151538680 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029414
 protein coding gene Chr4:136794814-136819611 (+)
PWK/PhJ MGP_PWKPhJ_G0027801
 protein coding gene Chr4:129724708-129731743 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027627
 protein coding gene Chr4:132607831-132636528 (+)
WSB/EiJ MGP_WSBEiJ_G0028159
 protein coding gene Chr4:136969058-136995435 (+)



Homology
more
  • Human Ortholog
    CNR2, cannabinoid receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNR2, cannabinoid receptor 2
  • Synonyms
    CB-2, CB2, CX5
  • Links
    NCBI Gene ID: 1269
    neXtProt AC: NX_P34972
    UniProt: P34972

  • Chr Location
    1p36.11; chr1:23870515-23913362 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    152 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Macrophages from homozygous mutant animals are resistant to the inhibitory effects of delta9-Tetrahydrocannabinol. Alopecia is seen in some but not all homozygotes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    883
  • Tissues
    82
  • cDNA Data
    14
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062585 Ensembl Gene Model | MGI Sequence Detail 24814 C57BL/6J ±  kb
    transcript ENSMUST00000068830 Ensembl | MGI Sequence Detail 3756 Not Applicable  
    polypeptide ENSMUSP00000069957 Ensembl | MGI Sequence Detail 347 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 5
      cDNA 14
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26090
    References
    more
    • Summaries
      All 224
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 152
    • Earliest
      J:46599 Munro S, et al., Molecular characterization of a peripheral receptor for cannabinoids [see comments]. Nature. 1993 Sep 2;365(6441):61-5
    • Latest
      J:352302 Sotzen M, et al., Characterization of the effects of cannabinoid receptor deletion on energy metabolism in female C57BL mice. Front Endocrinol (Lausanne). 2024;15:1386230
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory